3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3-hydroxy-6-iodo-4-trifluoromethyloxindole

Base Information

Chemical Name:3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3-hydroxy-6-iodo-4-trifluoromethyloxindole
CAS No.:259667-84-0
Molecular Formula:C₂₁H₂₁ClF₃IN₂O₂
Molecular Weight:552.763
Hs Code.:

Synonyms:3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3-hydroxy-6-iodo-4-trifluoromethyloxindole

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Chemical Property of 3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3-hydroxy-6-iodo-4-trifluoromethyloxindole

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Technology Process of 3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3-hydroxy-6-iodo-4-trifluoromethyloxindole

There total 5 articles about 3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3-hydroxy-6-iodo-4-trifluoromethyloxindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 89479-33-4
2-chlorophenylmagnesium iodide

: 259667-63-5
1-(2-diethylaminoethyl)-6-iodo-4-trifluoromethylisatin

: 259667-84-0
3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3-hydroxy-6-iodo-4-trifluoromethyloxindole

Guidance literature:: In diethyl ether; toluene;

Reference yield: 55.0%

: 36692-27-0
2-chlorophenylmagnesium bromide

: 259667-63-5
1-(2-diethylaminoethyl)-6-iodo-4-trifluoromethylisatin

: 259667-84-0
3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3-hydroxy-6-iodo-4-trifluoromethyloxindole

Guidance literature:: In diethyl ether; toluene; at 20 ℃; for 0.333333h;
DOI:10.1021/jm0103763

Reference yield:

: 98-46-4
3-trifluoromethylnitrobenzene

: 259667-84-0
3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3-hydroxy-6-iodo-4-trifluoromethyloxindole

Guidance literature:: Multi-step reaction with 4 steps

1: 21 percent / N-iodosuccimide; conc. H₂SO₄ / 6 h / 50 °C

2: 80 percent / SnCl₂*H₂O / ethanol / 1 h / Heating

3: 55 percent / diethyl ether; toluene / 0.33 h / 20 °C

With N-iodo-succinimide; sulfuric acid; tin(ll) chloride; In diethyl ether; ethanol; toluene;
DOI:10.1021/jm0103763