pyridin-2-yl-methyl carbamoyl methylcarbamic acid benzyl ester

Base Information

• Chemical Name: pyridin-2-yl-methyl carbamoyl methylcarbamic acid benzyl ester
• CAS No.: 71874-21-0
• Molecular Formula: C₁₆H₁₇N₃O₃
• Molecular Weight: 299.329
• Mol file: 71874-21-0.mol

Synonyms:pyridin-2-yl-methyl carbamoyl methylcarbamic acid benzyl ester

Chemical Property of pyridin-2-yl-methyl carbamoyl methylcarbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of pyridin-2-yl-methyl carbamoyl methylcarbamic acid benzyl ester

There total 4 articles about pyridin-2-yl-methyl carbamoyl methylcarbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(Aminomethyl)pyridine (3731-51-9) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → pyridin-2-yl-methyl carbamoyl methylcarbamic acid benzyl ester (71874-21-0)

Guidance literature:

With fluoroalkyl-containing substituted carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol701631m

Reference yield: 80.0%

benzyl N-benzyloxycarbonylglycinate (5513-38-2) + benzylamine (100-46-9) → pyridin-2-yl-methyl carbamoyl methylcarbamic acid benzyl ester (71874-21-0)

Guidance literature:

at 40 ℃; for 1.5h; in incubator;

DOI:10.1016/j.tetlet.2011.03.039

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → pyridin-2-yl-methyl carbamoyl methylcarbamic acid benzyl ester (71874-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2: 1.5 h / 40 °C / in incubator

With dmap; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.tetlet.2011.03.039

upstream raw materials:

2-(Aminomethyl)pyridine

N-(Benzyloxycarbonyl)glycine

benzyl N-benzyloxycarbonylglycinate

benzylamine