(R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoate

Base Information

• Chemical Name: (R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoate
• CAS No.: 1637740-90-9
• Molecular Formula: C₂₅H₂₇N₃O₃
• Molecular Weight: 417.508
• Mol file: 1637740-90-9.mol

Synonyms:(R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoate

Chemical Property of (R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoate

There total 1 articles about (R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3-methoxy-4-(methoxycarbonyl)phenyl)boronic acid (603122-41-4) + (R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile (1246765-10-5) → (R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoate (1637740-90-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; at 70 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm500206r

Reference yield: 43.0%

(R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoate (1637740-90-9) → (R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoic acid (1608471-44-8)

Guidance literature:

(R)-methyl 4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoate; With lithium hydroxide; In tetrahydrofuran; water; at 50 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; pH=4;

DOI:10.1021/jm500206r

upstream raw materials:

(3-methoxy-4-(methoxycarbonyl)phenyl)boronic acid

(R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

Downstream raw materials:

(R)-4-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoic acid