(R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

Base Information

Chemical Name:(R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile
CAS No.:1246765-10-5
Molecular Formula:C₁₆H₁₈ClN₃
Molecular Weight:287.792
Hs Code.:

Synonyms:(R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

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Chemical Property of (R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

Chemical Property:

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Technology Process of (R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

There total 5 articles about (R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246765-04-7
4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

: 1246765-10-5
(R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

: (S)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

Guidance literature:: With chiral Column AD-H; In carbon dioxide; isopropyl alcohol; optical yield given as %ee; Resolution of racemate;
DOI:10.1016/j.tetlet.2011.10.052

Reference yield:

: 1246765-04-7
4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

: 1246765-10-5
(R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

Guidance literature:: With chiral SFC Column AD-H 30 x 250 mm; In carbon dioxide; isopropyl alcohol; Purification / work up; Resolution of racemate;

Reference yield:

: 1246765-08-1
4-(5-cyclopentyl-3-oxopyrazolidin-1-yl)-2-methylbenzonitrile

: 1246765-10-5
(R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / acetonitrile / 20 - 80 °C

2: chiral Column AD-H / carbon dioxide; isopropyl alcohol / Resolution of racemate

With trichlorophosphate; In carbon dioxide; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.tetlet.2011.10.052