(S)-9-amino-N-(4-fluorobenzyl)-8-oxo-2,7,13-triaza-1(2,4)-pyrimidinacyclotridecaphane-1-carboxamide

Base Information

Chemical Name:(S)-9-amino-N-(4-fluorobenzyl)-8-oxo-2,7,13-triaza-1(2,4)-pyrimidinacyclotridecaphane-1-carboxamide
CAS No.:1612782-97-4
Molecular Formula:C₂₁H₂₈FN₇O₂
Molecular Weight:429.497
Hs Code.:

Synonyms:(S)-9-amino-N-(4-fluorobenzyl)-8-oxo-2,7,13-triaza-1(2,4)-pyrimidinacyclotridecaphane-1-carboxamide

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Chemical Property of (S)-9-amino-N-(4-fluorobenzyl)-8-oxo-2,7,13-triaza-1(2,4)-pyrimidinacyclotridecaphane-1-carboxamide

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Technology Process of (S)-9-amino-N-(4-fluorobenzyl)-8-oxo-2,7,13-triaza-1(2,4)-pyrimidinacyclotridecaphane-1-carboxamide

There total 7 articles about (S)-9-amino-N-(4-fluorobenzyl)-8-oxo-2,7,13-triaza-1(2,4)-pyrimidinacyclotridecaphane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1612783-51-3
(S)-9-((tert-butoxycarbonyl)amino)-8-oxo-2,7,13-triaza-1(2,4)-pyrimidinacyclotridecaphane-1-carboxylic acid

: 140-75-0
para-fluorobenzylamine

: 1612782-97-4
(S)-9-amino-N-(4-fluorobenzyl)-8-oxo-2,7,13-triaza-1(2,4)-pyrimidinacyclotridecaphane-1-carboxamide

Guidance literature:: (S)-9-((tert-butoxycarbonyl)amino)-8-oxo-2,7,13-triaza-1(2,4)-pyrimidinacyclotridecaphane-1-carboxylic acid; para-fluorobenzylamine; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 2h;

Reference yield:

: C₂₆H₃₆FN₇O₄

: 1612782-97-4
(S)-9-amino-N-(4-fluorobenzyl)-8-oxo-2,7,13-triaza-1(2,4)-pyrimidinacyclotridecaphane-1-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 3177-20-6
2,4-dichloro-5-pyrimidinecarboxylic acid methyl ester

: 1612782-97-4
(S)-9-amino-N-(4-fluorobenzyl)-8-oxo-2,7,13-triaza-1(2,4)-pyrimidinacyclotridecaphane-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; isopropyl alcohol / 2.5 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol; N,N-dimethyl-formamide / 1 h / 20 - 45 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4.1: lithium hydroxide; water / tetrahydrofuran / 75 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

5.2: 2 h / 20 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;