Methyl2,4-Dichloropyrimidine-5-carboxylate

Base Information

• Chemical Name: Methyl2,4-Dichloropyrimidine-5-carboxylate
• CAS No.: 3177-20-6
• Molecular Formula: C6H4Cl2N2O2
• Molecular Weight: 207.016
• Hs Code.: 29335990
• Mol file: 3177-20-6.mol

Synonyms:2,4-Dichloropyrimidine-5-carboxylicacid methyl ester;Methyl 2,4-dichloro-5-pyrimidinecarboxylate;

Chemical Property of Methyl2,4-Dichloropyrimidine-5-carboxylate

Chemical Property:

• Vapor Pressure: 0.0012mmHg at 25°C
• Melting Point: 30-34 °C
• Refractive Index: 1.552
• Boiling Point: 299.3 °C at 760 mmHg
• PKA: -4.55±0.29(Predicted)
• Flash Point: 134.8 °C
• PSA: 52.08000
• Density: 1.503 g/cm³
• LogP: 1.57000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2,4-dichloropyrimidine-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 26-36/37/38-22
• Safety Statements: 26-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of Methyl2,4-Dichloropyrimidine-5-carboxylate

There total 3 articles about Methyl2,4-Dichloropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 2,4-dichloropyrimidine-5-carbonyl chloride (2972-52-3) → 2,4-dichloro-5-pyrimidinecarboxylic acid methyl ester (3177-20-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

methyl 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (42821-92-1) → 2,4-dichloro-5-pyrimidinecarboxylic acid methyl ester (3177-20-6)

Guidance literature:

In 2-Methylpentane; trichlorophosphate;

Reference yield:

→ 2,4-dichloro-5-pyrimidinecarboxylic acid methyl ester (3177-20-6)

Guidance literature:

/BRN= 147987/;

DOI:10.1021/jo01125a004

upstream raw materials:

methyl 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

methanol

2,4-dichloropyrimidine-5-carbonyl chloride

Downstream raw materials:

ethyl 4-amino-2-chloropyrimidine-5-carboxylate

methyl 2-chloro-4-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenylamino]-pyrimidine-5-carboxylate

2-(butylamino)-4-[(4-hydroxycyclohexyl)amino]-N-{[4-(1H-imidazol-1-yl)phenyl]methyl}pyrimidine-5-carboxamide

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