GLPG-0974

Base Information

Chemical Name:GLPG-0974
CAS No.:1391076-61-1
Molecular Formula:C₂₅H₂₅ClN₂O₄S
Molecular Weight:485.004
Hs Code.:

Synonyms:GLPG-0974

Suppliers and Price of GLPG-0974

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
GLPG0974
2.5mg
$ 260.00

Cayman Chemical
GLPG0974
5mg
$ 110.00

Cayman Chemical
GLPG0974
1mg
$ 49.00

AK Scientific
CID57520598
1mg
$ 166.00

Total 6 raw suppliers

Chemical Property of GLPG-0974

Chemical Property:

Boiling Point:726.3±60.0 °C(Predicted)
Density:1.374±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

GLPG0974 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses GLPG 0974 is a potent FFA2 antagonist.

Technology Process of GLPG-0974

There total 12 articles about GLPG-0974 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1391078-75-3
4-[[(R)-1-(benzo[b]thiophene-3-carbonyl)-2-methylazetidine-2-carbonyl]-(3-chlorobenzyl)amino]butyric acid methyl ester

: 1391076-61-1
GLPG-0974

Guidance literature:: 4-[[(R)-1-(benzo[b]thiophene-3-carbonyl)-2-methylazetidine-2-carbonyl]-(3-chlorobenzyl)amino]butyric acid methyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; for 15h;

With hydrogenchloride; In methanol; water; pH=2;

Reference yield:

: 1391077-69-2
2-[benzyl-(2-chloroethyl)amino]propionic acid ethyl ester

: 1391076-61-1
GLPG-0974

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

1.2: 0.17 h / 20 °C

2.1: hydrogen / palladium on activated charcoal / ethanol / 24 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / ethanol / 15 h / 20 °C

3.2: pH 5

4.1: chiralpak AD-H / hexane; ethanol; formic acid / 20 °C / Resolution of racemate

5.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

5.2: 2.5 h / -5 - 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; tetrahydrofuran / 15 h / 20 °C

7.2: 4.5 h / 20 °C

8.1: sodium hydroxide; water / methanol / 15 h / 20 °C

8.2: pH 2

With hydrogenchloride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; water; hydrogen; potassium hexamethylsilazane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; formic acid; ethanol; hexane; dichloromethane; toluene;

Reference yield:

: 1391077-71-6
1-benzyl-2-methylazetidine-2-carboxylic acid ethyl ester

: 1391076-61-1
GLPG-0974

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 24 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 15 h / 20 °C

2.2: pH 5

3.1: chiralpak AD-H / hexane; ethanol; formic acid / 20 °C / Resolution of racemate

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 2.5 h / -5 - 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; tetrahydrofuran / 15 h / 20 °C

6.2: 4.5 h / 20 °C

7.1: sodium hydroxide; water / methanol / 15 h / 20 °C

7.2: pH 2

With hydrogenchloride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; formic acid; ethanol; hexane; dichloromethane;