N-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

Base Information

• Chemical Name: N-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine
• CAS No.: 1075253-40-5
• Molecular Formula: C₂₀H₁₂F₆N₆O₂S
• Molecular Weight: 514.411

Synonyms:N-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

Chemical Property of N-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

Chemical Property:

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98% ^*data from raw suppliers

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Technology Process of N-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

There total 1 articles about N-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

2-chloro-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]pyridine (1075253-39-2) + 2,4-bis(trifluoromethyl)aniline (367-71-5) → N-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine (1075253-40-5)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; In 1,2-dimethoxyethane; at 100 ℃; for 0.333333h; under 3102.97 Torr; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jm800743q

Reference yield: 25.0%

N-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine (1075253-40-5) → N2-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine (1075253-41-6)

Guidance literature:

With sodium dithionite; water; In acetonitrile; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/jm800743q

upstream raw materials:

2-chloro-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]pyridine

2,4-bis(trifluoromethyl)aniline

Downstream raw materials:

N₂-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine

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