367-71-5

Basic information

• Product Name: 2,4-BIS(TRIFLUOROMETHYL)ANILINE
• Synonyms: 2,4-BIS(TRIFLUOROMETHYL)ANILINE;2,4-Bis(trifluoromethyl)aniline 98%;2,4-Bis(trifluoromethyl)aniline98%;2,4-Ditrifluoromethylaniline;2,4-Bis(trifluoromethyl)aniline 97+%;BenzenaMine,2,4-bis(trifluoroMethyl)-;alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-2,4-xylidine
• CAS NO: 367-71-5
• Molecular Formula: C₈H₅F₆N
• Molecular Weight: 229.12
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 367-71-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 50°C 0,4mm
• Flash Point: 50°C/0.4mm
• Appearance: /
• Density: 1.443 g/cm³
• Vapor Pressure: 1.17mmHg at 25°C
• Refractive Index: 1.4372
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.37±0.10(Predicted)
• BRN: 3319910
• CAS DataBase Reference: 2,4-BIS(TRIFLUOROMETHYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-BIS(TRIFLUOROMETHYL)ANILINE(367-71-5)
• EPA Substance Registry System: 2,4-BIS(TRIFLUOROMETHYL)ANILINE(367-71-5)

Safety Data

• Hazard Codes: T,Xn,Xi
• Statements: 23/24/25-33-36/38-36/37/38-20/21/22-52-36
• Safety Statements: 36/37/39-45-36-26
• RIDADR: 2810
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 367-71-5(Hazardous Substances Data)

Usage

General Description

"2,4-Bis(trifluoromethyl)aniline" is a chemical compound that belongs to the class of organic compounds known as anilines. These compounds are characterized by a phenyl group attached to an amino group. The unique feature of 2,4-Bis(trifluoromethyl)aniline is the presence of two trifluoromethyl groups, which are groups consisting of one carbon atom and three fluorine atoms, on the phenyl ring. This particular structure can make the compound more stable and resistant to reacting with other substances. It's often used in the synthesis of various pharmaceuticals and organic materials due to its chemical properties. However, like many aniline derivatives, it may have toxic properties, underlining the necessity for appropriate handling and use.

InChI:InChI=1/C8H5F6N/c9-7(10,11)4-1-2-6(15)5(3-4)8(12,13)14/h1-3H,15H2

Upstream product

• 2314-97-8 iodotrifluoromethane 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 455-14-1 4-trifluoromethylphenylamine 
• 2926-29-6 Langlois reagent 
• 887144-94-7 Togni's reagent II 
• 2377-34-6 N-(2,4-bis-trifluoromethyl-phenyl)-phthalimide 

Downstream Products

• 949536-16-7 C₂₉H₃₉F₆N₃OSi 
• 476645-29-1 C₃₁H₄₃F₆N₃OSi 
• 1220913-16-5 2,4-bis(trifluoromethyl)aniline-3,5-dibromosalicylaldimine 
• 1361510-33-9 (S)-(9H-fluoren-9-yl)methyl 1-(2,4-bis(trifluoromethyl)phenylamino)-3-methyl-1-selenoxobutan-2-ylcarbamate 
• 1361510-24-8 C₂₈H₂₄F₆N₂O₃ 
• 1420299-72-4 N,N-diethyl-2,4-bis(trifluoromethyl)aniline 
• 1402134-63-7 [2,4-bis(trifluoromethyl)phenyl]hydrazine 
• 1402134-68-2 (1E,2E)-1-{2-[2,4-bis(trifluoromethyl)phenyl]hydrazono}non-2-en-4-ol 
• 1402134-81-9 (E)-1-[2,4-bis(trifluoromethyl)phenyl]-2-[(E)-4-{2-[2,4-bis(trifluoromethyl)phenyl]hydrazinyl}non-2-enylidene]hydrazine 
• 491864-84-7 C₂₈H₃₁F₆N₅OSSi 

Relevant articles and documents

Transition metal-free direct C–H trifluoromethyltion of (hetero)arenes with Togni's reagent

A new transition-metal-free direct C–H trifluoromethylation reaction of (hetero)arenes with Togni's reagent was developed. This transformation proceeded smoothly under mild conditions and exhibited good tolerance of many synthetically relevant functional groups. It provided an alternative approach for the synthesis of trifluoromethylated (hetero)arenes.

Preparation method of trifluoromethylamine

The invention relates to a preparation method of trifluoromethylamine. The method includes the following steps that aromatic amine shown in the formula (1) and a trifluoromethyl reagent shown in the formula (2) react in a solvent under the condition that an alkali and/or nickel compound exists, and the trifluoromethylamine compound shown in the formula (3) is generated. According to the preparation method of trifluoromethylamine, aromatic amine and 1-trifluoromethyl-1,2-iodobenzoyl-3(H)-ketone serve as raw materials and react under the condition that the alkali and/or nickel compound exists through the amino positioning effect on aromatic nucleus. The synthesis steps of the method are simple, the cost of the raw materials is low, the production cost of trifluoromethylamine can be greatly reduced, and large-scale industrialized production is promoted.

Copper-free direct C-H trifluoromethylation of acetanilides with sodium trifluoromethanesulfinate

A copper-free direct C-H ortho trifluoromethylation of electron-deficient 4-substituted acetanilides using Langlois reagent (NaSO2CF3) as the CF3 source in the presence of tert-butyl hydroperoxide (tBuOOH, TBHP) was developed.