2-(benzyloxy)-4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-6-methylpyridine-3-carbonitrile

Base Information

Chemical Name:2-(benzyloxy)-4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-6-methylpyridine-3-carbonitrile
CAS No.:1616288-57-3
Molecular Formula:C₂₁H₂₈N₂O₂Si
Molecular Weight:368.551
Hs Code.:

Synonyms:2-(benzyloxy)-4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-6-methylpyridine-3-carbonitrile

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Chemical Property of 2-(benzyloxy)-4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-6-methylpyridine-3-carbonitrile

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Technology Process of 2-(benzyloxy)-4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-6-methylpyridine-3-carbonitrile

There total 3 articles about 2-(benzyloxy)-4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-6-methylpyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1396780-70-3
4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 100-44-7
benzyl chloride

: 1616288-57-3
2-(benzyloxy)-4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-6-methylpyridine-3-carbonitrile

Guidance literature:: With silver(l) oxide; In toluene; at 100 ℃; for 21h;

Reference yield:

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 1616288-57-3
2-(benzyloxy)-4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-6-methylpyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 0.17 h / -20 - -10 °C

2: potassium tert-butylate / dimethyl sulfoxide / 2 h / 0 °C

3: silver(l) oxide / toluene / 21 h / 100 °C

With potassium tert-butylate; isopropylmagnesium chloride; lithium chloride; silver(l) oxide; In tetrahydrofuran; dimethyl sulfoxide; toluene;

Reference yield:

: 81535-82-2
5-<(tert-butyldimethylsilyl)oxy>-3-pentyn-2-one

: 1616288-57-3
2-(benzyloxy)-4-({[tert-butyl(dimethyl)-silyl]oxy}methyl)-6-methylpyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / dimethyl sulfoxide / 2 h / 0 °C

2: silver(l) oxide / toluene / 21 h / 100 °C

With potassium tert-butylate; silver(l) oxide; In dimethyl sulfoxide; toluene;