2-(benzyloxy)-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(chloromethyl)-6-methylpyridine

Base Information

Chemical Name:2-(benzyloxy)-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(chloromethyl)-6-methylpyridine
CAS No.:1616288-61-9
Molecular Formula:C₂₁H₃₀ClNO₂Si
Molecular Weight:392.013
Hs Code.:

Synonyms:2-(benzyloxy)-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(chloromethyl)-6-methylpyridine

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Chemical Property of 2-(benzyloxy)-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(chloromethyl)-6-methylpyridine

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Technology Process of 2-(benzyloxy)-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(chloromethyl)-6-methylpyridine

There total 5 articles about 2-(benzyloxy)-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(chloromethyl)-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1616288-59-5
[2-(benzyloxy)-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-6-methylpyridin-3-yl]methanol

: 1616288-61-9
2-(benzyloxy)-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(chloromethyl)-6-methylpyridine

Guidance literature:: With N-chloro-succinimide; dimethylsulfide; In dichloromethane; at -40 - 20 ℃; for 3h;

Reference yield:

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 1616288-61-9
2-(benzyloxy)-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(chloromethyl)-6-methylpyridine

Guidance literature:: Multi-step reaction with 5 steps

1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 0.17 h / -20 - -10 °C

2: potassium tert-butylate / dimethyl sulfoxide / 2 h / 0 °C

3: silver(l) oxide / toluene / 21 h / 100 °C

4: sodium tetrahydroborate / methanol / 24 h / 20 °C

5: dimethylsulfide; N-chloro-succinimide / dichloromethane / 3 h / -40 - 20 °C

With sodium tetrahydroborate; N-chloro-succinimide; dimethylsulfide; potassium tert-butylate; isopropylmagnesium chloride; lithium chloride; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 81535-82-2
5-<(tert-butyldimethylsilyl)oxy>-3-pentyn-2-one

: 1616288-61-9
2-(benzyloxy)-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(chloromethyl)-6-methylpyridine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / dimethyl sulfoxide / 2 h / 0 °C

2: silver(l) oxide / toluene / 21 h / 100 °C

3: sodium tetrahydroborate / methanol / 24 h / 20 °C

4: dimethylsulfide; N-chloro-succinimide / dichloromethane / 3 h / -40 - 20 °C

With sodium tetrahydroborate; N-chloro-succinimide; dimethylsulfide; potassium tert-butylate; silver(l) oxide; In methanol; dichloromethane; dimethyl sulfoxide; toluene;