2-{2-[(Dimethyl-phenyl-silanyl)-methyl]-phenyl}-4,4-dimethyl-4,5-dihydro-oxazole

Base Information

Chemical Name:2-{2-[(Dimethyl-phenyl-silanyl)-methyl]-phenyl}-4,4-dimethyl-4,5-dihydro-oxazole
CAS No.:215546-42-2
Molecular Formula:C₂₀H₂₅NOSi
Molecular Weight:323.51
Hs Code.:

Synonyms:2-{2-[(Dimethyl-phenyl-silanyl)-methyl]-phenyl}-4,4-dimethyl-4,5-dihydro-oxazole

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Chemical Property of 2-{2-[(Dimethyl-phenyl-silanyl)-methyl]-phenyl}-4,4-dimethyl-4,5-dihydro-oxazole

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Technology Process of 2-{2-[(Dimethyl-phenyl-silanyl)-methyl]-phenyl}-4,4-dimethyl-4,5-dihydro-oxazole

There total 1 articles about 2-{2-[(Dimethyl-phenyl-silanyl)-methyl]-phenyl}-4,4-dimethyl-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 768-33-2
phenyldimethylsilyl chloride

: 71885-44-4
4,5-dihydro-4,4-dimethyl-2-(2-methylphenyl)-2-oxazoline

: 215546-42-2
2-{2-[(Dimethyl-phenyl-silanyl)-methyl]-phenyl}-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: With n-butyllithium; In diethyl ether; hexane; 1.) 0 deg C, 30 min, 2.) 0 deg C, 2 h;

Reference yield: 86.0%

: 215546-42-2
2-{2-[(Dimethyl-phenyl-silanyl)-methyl]-phenyl}-4,4-dimethyl-4,5-dihydro-oxazole

: 74-88-4
methyl iodide

: 215546-07-9
2-{2-[1-(Dimethyl-phenyl-silanyl)-ethyl]-phenyl}-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: With n-butyllithium; In diethyl ether; hexane; 1.) 0 deg C, 1 h, 2.) 1 h;

Reference yield:

: 215546-42-2
2-{2-[(Dimethyl-phenyl-silanyl)-methyl]-phenyl}-4,4-dimethyl-4,5-dihydro-oxazole

: (R)-1-{2-[(R)-1-(Dimethyl-phenyl-silanyl)-ethyl]-phenyl}-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / n-BuLi / hexane; diethyl ether / 1.) 0 deg C, 1 h, 2.) 1 h

2: nitromethane / 20.5 h

3: 2.) HCl, H₂O / 1.) Et₂O, THF, 15 min, 2.) EtOH, 1.5

4: 53 percent / sodium bis(2-methoxyethoxy)aluminium hydride / diethyl ether / 0.17 h / 0 °C

5: 1.) EtO₂CN=NCO₂Et, PPh₃, HCO₂H, 2.) K₂CO₃ / 2.) H₂O, EtOH

With hydrogenchloride; n-butyllithium; formic acid; water; potassium carbonate; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; diethylazodicarboxylate; In diethyl ether; nitromethane; hexane;