(4,6-dimethyl-pyrimidin-5-yl)-{5-[3-(3-fluoro-phenyl)-3-(1-methanesulfonyl-piperidin-4-yl)-1-methyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone

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Chemical Name:(4,6-dimethyl-pyrimidin-5-yl)-{5-[3-(3-fluoro-phenyl)-3-(1-methanesulfonyl-piperidin-4-yl)-1-methyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone
CAS No.:1014702-44-3
Molecular Formula:C₂₉H₄₀FN₅O₃S
Molecular Weight:557.733
Hs Code.:

(4,6-dimethyl-pyrimidin-5-yl)-{5-[3-(3-fluoro-phenyl)-3-(1-methanesulfonyl-piperidin-4-yl)-1-methyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone

Synonyms:(4,6-dimethyl-pyrimidin-5-yl)-{5-[3-(3-fluoro-phenyl)-3-(1-methanesulfonyl-piperidin-4-yl)-1-methyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone

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Chemical Property of (4,6-dimethyl-pyrimidin-5-yl)-{5-[3-(3-fluoro-phenyl)-3-(1-methanesulfonyl-piperidin-4-yl)-1-methyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone

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Technology Process of (4,6-dimethyl-pyrimidin-5-yl)-{5-[3-(3-fluoro-phenyl)-3-(1-methanesulfonyl-piperidin-4-yl)-1-methyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone

There total 12 articles about (4,6-dimethyl-pyrimidin-5-yl)-{5-[3-(3-fluoro-phenyl)-3-(1-methanesulfonyl-piperidin-4-yl)-1-methyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1014703-41-3
C₂₈H₃₈FN₅O

: 124-63-0
methanesulfonyl chloride

: 1014702-44-3
(4,6-dimethyl-pyrimidin-5-yl)-{5-[3-(3-fluoro-phenyl)-3-(1-methanesulfonyl-piperidin-4-yl)-1-methyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 878130-44-0
4-(3-fluoro-phenyl)-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1014702-44-3
(4,6-dimethyl-pyrimidin-5-yl)-{5-[3-(3-fluoro-phenyl)-3-(1-methanesulfonyl-piperidin-4-yl)-1-methyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hypochlorite; sodium carbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 20 °C

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

2.2: 20 °C

3.1: tetrahydrofuran / 6 h / -78 - 20 °C

4.1: titanium(IV) isopropylate / tetrahydrofuran; dichloromethane / 0.17 h / 20 °C

4.2: 4 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

6.1: triethylamine / dichloromethane / 1 h / 0 °C

With titanium(IV) isopropylate; sodium hypochlorite; sodium carbonate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 644982-64-9
1,1-dimethylethyl 4-[1-cyano-2-(ethyloxy)-2-oxoethyl]-4-(3-fluorophenyl)-1-piperidinecarboxylate

: 1014702-44-3
(4,6-dimethyl-pyrimidin-5-yl)-{5-[3-(3-fluoro-phenyl)-3-(1-methanesulfonyl-piperidin-4-yl)-1-methyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-methanone

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / ethanol; water / 15 h / 20 °C

1.2: 0 °C / pH 3

2.1: copper(I) oxide / acetonitrile / 1 - 1.25 h / Heating / reflux

3.1: diisobutylaluminium hydride / dichloromethane / 4 h / -78 - -60 °C

4.1: sodium hypochlorite; sodium carbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 20 °C

5.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

5.2: 20 °C

6.1: tetrahydrofuran / 6 h / -78 - 20 °C

7.1: titanium(IV) isopropylate / tetrahydrofuran; dichloromethane / 0.17 h / 20 °C

7.2: 4 h / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

9.1: triethylamine / dichloromethane / 1 h / 0 °C

With copper(I) oxide; titanium(IV) isopropylate; sodium hydroxide; sodium hypochlorite; diisobutylaluminium hydride; sodium carbonate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;