2'-triethylsilyl-7-(-acetyl)paclitaxel

Base Information

• Chemical Name: 2'-triethylsilyl-7-(-acetyl)paclitaxel
• CAS No.: 220167-83-9
• Molecular Formula: C₅₅H₆₇NO₁₅Si
• Molecular Weight: 1012.21

Synonyms:2'-triethylsilyl-7-(-acetyl)paclitaxel

Chemical Property of 2'-triethylsilyl-7-(-acetyl)paclitaxel

Chemical Property:

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Technology Process of 2'-triethylsilyl-7-(-acetyl)paclitaxel

There total 2 articles about 2'-triethylsilyl-7-(-acetyl)paclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-[14C]-acetic anhydride (2742-27-0) + (2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate (148930-54-5) → 2'-triethylsilyl-7-(-acetyl)paclitaxel (220167-83-9)

Guidance literature:

With pyridine; dmap; for 20h; Ambient temperature;

DOI:10.1016/S0968-0896(98)00158-8

Reference yield: 52.0%

[1-14C]acetic acid sodium salt (993-04-4) + (2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate (148930-54-5) → 2'-triethylsilyl-7-(-acetyl)paclitaxel (220167-83-9)

Guidance literature:

With pyridine; In tetrahydrofuran; water; at 80 ℃; for 20h;

DOI:10.1016/S0968-0896(98)00158-8

Reference yield: 90.0%

2'-triethylsilyl-7-(-acetyl)paclitaxel (220167-83-9) → 7-(-acetyl)paclitaxel

Guidance literature:

With acetic acid; In tetrahydrofuran; water; for 24h; Ambient temperature;

DOI:10.1016/S0968-0896(98)00158-8

upstream raw materials:

1-[14C]-acetic anhydride

(2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

[1-14C]acetic acid sodium salt

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