ALW-II-49-7

Base Information

Chemical Name:ALW-II-49-7
CAS No.:1135219-23-6
Molecular Formula:C₂₁H₁₇F₃N₄O₂
Molecular Weight:414.387
Hs Code.:

Synonyms:ALW-II-49-7

Suppliers and Price of ALW-II-49-7

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of ALW-II-49-7

Chemical Property:

Boiling Point:522.8±50.0 °C(Predicted)
Density:1.399±0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of ALW-II-49-7

There total 4 articles about ALW-II-49-7 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 28733-43-9
5-bromonicotinamide

: 30069-31-9
N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide

: 1135219-23-6
ALW-II-49-7

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate; In toluene; at 80 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.bmcl.2009.05.029

Reference yield:

: 23410-19-7
3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

: 28733-43-9
5-bromonicotinamide

: 1135219-23-6
ALW-II-49-7

Guidance literature:: 3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide; 5-bromonicotinamide; With potassium carbonate; In tert-butyl alcohol; for 0.0833333h; Inert atmosphere;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tert-butyl alcohol; at 75 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.matbio.2016.11.009

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1135219-23-6
ALW-II-49-7

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

2.1: tin(ll) chloride / ethyl acetate; ethanol / 5 h / 80 °C

3.1: potassium carbonate / tert-butyl alcohol / 0.08 h / Inert atmosphere

3.2: 5 h / 75 °C / Inert atmosphere

With dmap; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tin(ll) chloride; In ethanol; dichloromethane; ethyl acetate; tert-butyl alcohol;
DOI:10.1016/j.matbio.2016.11.009