2-(4-Chlorobenzyl)benzimidazole

Base Information

• Chemical Name: 2-(4-Chlorobenzyl)benzimidazole
• CAS No.: 5468-66-6
• Molecular Formula: C14H11ClN2
• Molecular Weight: 242.708
• Hs Code.: 2933990090
• Mol file: 5468-66-6.mol

Synonyms:Benzimidazole,2-p-chlorobenzyl- (6CI);2-(p-Chlorobenzyl)benzimidazole;NSC 15003;

Chemical Property of 2-(4-Chlorobenzyl)benzimidazole

Chemical Property:

• Appearance/Colour: purple-pinkish crystalline powder
• Vapor Pressure: 6.71E-09mmHg at 25°C
• Melting Point: 203-207
• Refractive Index: 1.684
• Boiling Point: 479.7 °C at 760 mmHg
• PKA: 11.72±0.10(Predicted)
• Flash Point: 276.1 °C
• PSA: 28.68000
• Density: 1.301 g/cm³
• LogP: 3.80710
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.5% ^*data from raw suppliers

2-(4-Chlorobenzyl)benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 37/39-26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Chlorobenzyl)benzimidazole

There total 3 articles about 2-(4-Chlorobenzyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chlorophenylacetic Acid (1878-66-6) + 1,2-diamino-benzene (95-54-5) → 2-(4-chlorobenzyl)-1H-benzo[d]imidazole (5468-66-6)

Guidance literature:

4-chlorophenylacetic Acid; With sodium benzoate; at 110 ℃;

1,2-diamino-benzene; at 120 ℃; for 1h;

Reference yield: 84.0%

4-n-chlorophenylacetylene (873-73-4) + 1,2-diamino-benzene (95-54-5) → 2-(4-chlorobenzyl)-1H-benzo[d]imidazole (5468-66-6)

Guidance literature:

4-n-chlorophenylacetylene; 1,2-diamino-benzene; With copper(l) iodide; 4-toluenesulfonyl azide; triethylamine; In acetonitrile; at 20 ℃; for 6h; Inert atmosphere;

With sulfuric acid; In acetonitrile; for 4h; Reflux;

DOI:10.1055/s-0029-1217515

Reference yield:

2-(4-Chlorophenyl)ethanol (1875-88-3) + 1,2-diamino-benzene (95-54-5) → 2-(4-chlorobenzyl)-1H-benzo[d]imidazole (5468-66-6)

Guidance literature:

With 1,3,5-trimethyl-benzene; at 150 ℃; for 18h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c5cy01601k

upstream raw materials:

4-chlorophenylacetic Acid

1,2-diamino-benzene

4-n-chlorophenylacetylene

2-(4-Chlorophenyl)ethanol

Downstream raw materials:

{2-[2-(4-chloro-benzyl)-benzoimidazol-1-yl]-ethyl}-dimethyl-amine

{2-[2-(4-chloro-benzyl)-benzoimidazol-1-yl]-ethyl}-diethyl-amine

2-(4-chlorobenzyl)-1-methyl-1H-benzo[d]imidazole