4-chloro-7-(2,4-diMethoxybenzyl)-5H-pyrrolo[2,3-d]pyriMidin-6(7H)-one

Base Information

Chemical Name:4-chloro-7-(2,4-diMethoxybenzyl)-5H-pyrrolo[2,3-d]pyriMidin-6(7H)-one
CAS No.:1226804-67-6
Molecular Formula:C₁₅H₁₄ClN₃O₃
Molecular Weight:319.747
Hs Code.:
Mol file:1226804-67-6.mol

Synonyms:4-chloro-7-(2,4-dimethoxybenzyl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Property of 4-chloro-7-(2,4-diMethoxybenzyl)-5H-pyrrolo[2,3-d]pyriMidin-6(7H)-one

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Technology Process of 4-chloro-7-(2,4-diMethoxybenzyl)-5H-pyrrolo[2,3-d]pyriMidin-6(7H)-one

There total 5 articles about 4-chloro-7-(2,4-diMethoxybenzyl)-5H-pyrrolo[2,3-d]pyriMidin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.05%

: 1226804-63-2
methyl 2-(4-chloro-6-(2,4-dimethoxybenzylamino)pyrimidin-5-yl)acetate

: 1226804-67-6
4-chloro-7-(2,4-dimethoxybenzyl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: methyl 2-(4-chloro-6-(2,4-dimethoxybenzylamino)pyrimidin-5-yl)acetate; With toluene-4-sulfonic acid; In toluene; for 1h; Reflux;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: C₁₇H₂₀ClN₃O₄

: 1226804-67-6
4-chloro-7-(2,4-dimethoxybenzyl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: C₁₇H₂₀ClN₃O₄; With toluene-4-sulfonic acid; In toluene; at 85 - 90 ℃; for 2h;

With sodium hydrogencarbonate; In water; toluene; at 80 - 85 ℃; pH=6.5 - 7;

Reference yield:

: 40967-67-7
trimethyl ethane-1,1,2-tricarboxylate

: 1226804-67-6
4-chloro-7-(2,4-dimethoxybenzyl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / methanol / 0 - 25 °C / Inert atmosphere

2: trichlorophosphate

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 60 °C / Inert atmosphere

4: toluene / 2 - 85 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-0031-1290408