2',3'-Didehydro-2',3'-dideoxy-5'-acetate inosine

Base Information

• Chemical Name: 2',3'-Didehydro-2',3'-dideoxy-5'-acetate inosine
• CAS No.: 130676-57-2
• Molecular Formula: C₁₂H₁₂N₄O₄
• Molecular Weight: 276.252
• Mol file: 130676-57-2.mol

Synonyms:2',3'-Didehydro-2',3'-dideoxy-inosine 5'-acetate

Chemical Property of 2',3'-Didehydro-2',3'-dideoxy-5'-acetate inosine

Chemical Property:

• PSA: 99.10000
• Density: 1.6 g/cm³
• LogP: 0.13630

Purity/Quality:

99% ^*data from raw suppliers

2',3'-Didehydro-2',3'-dideoxy-5'-acetate inosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2'',3''-Didehydro-2'',3''-dideoxy-5''-acetate Inosine is an impurity of Inosine Pranobex, a formulation that is known to positively impact a host’s immune system.

Technology Process of 2',3'-Didehydro-2',3'-dideoxy-5'-acetate inosine

There total 6 articles about 2',3'-Didehydro-2',3'-dideoxy-5'-acetate inosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)-1,9-dihydro-6H-purine-6-one (125790-82-1) → 1-(5-O-Acetyl-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)hypoxanthine (130676-57-2)

Guidance literature:

With tetraethylammonium tosylate; In methanol; Electrolysis;

DOI:10.1081/NCN-100002532

Reference yield: 73.0%

5'-O-acetyl-3'-deoxy-3'β-bromoinosine → 1-(5-O-Acetyl-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)hypoxanthine (130676-57-2)

Guidance literature:

With Nonafluorobutanesulfonyl fluoride; triethylamine; In acetonitrile; at 70 ℃; for 2h;

Reference yield:

acetic anhydride (108-24-7) + Inosine (58-63-9) → 5'-O-acetyl-2',3'-didehydro-2',3'-dideoxyinosine (130676-57-2)

Guidance literature:

Inosine; With acetoxyisobutyryl bromide; In acetonitrile; at 20 ℃; for 10h;

acetic anhydride; With pyridine; at 20 ℃; for 0.5h;

With copper; acetic acid; zinc; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1016/S0040-4020(01)00800-6

upstream raw materials:

9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)-1,9-dihydro-6H-purine-6-one

2',3'-O-(1-methoxyethylidene)inosine

Inosine

acetic anhydride

Downstream raw materials:

O⁶-benzyl-5'-O-dibenzyloxyphosphoryl-2',3'-dideoxyinosine

5'-O-acetyl-2',3'-dideoxy-O⁶-(2,4,6-triisopropylbenzenesulfonyl)inosine

2',3'-dideoxy-O⁶-(2,4,6-triisopropylbenzenesulfonyl)inosine

O⁶-benzyl-2',3'-dideoxyinosine

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