9-ethyl-6,9-dihydroxy-7-methyl-1-(phenylsulfinyl)-spirononane-3,2'-<1,3>dioxolane>

Base Information

Chemical Name:9-ethyl-6,9-dihydroxy-7-methyl-1-(phenylsulfinyl)-spirononane-3,2'-<1,3>dioxolane>
CAS No.:145095-38-1
Molecular Formula:C₂₀H₂₈O₅S
Molecular Weight:380.505
Hs Code.:

9-ethyl-6,9-dihydroxy-7-methyl-1-(phenylsulfinyl)-spiro<bicyclo<3.3.1>nonane-3,2'-<1,3>dioxolane>

Synonyms:9-ethyl-6,9-dihydroxy-7-methyl-1-(phenylsulfinyl)-spirononane-3,2'-<1,3>dioxolane>

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Chemical Property of 9-ethyl-6,9-dihydroxy-7-methyl-1-(phenylsulfinyl)-spirononane-3,2'-<1,3>dioxolane>

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Technology Process of 9-ethyl-6,9-dihydroxy-7-methyl-1-(phenylsulfinyl)-spirononane-3,2'-<1,3>dioxolane>

There total 5 articles about 9-ethyl-6,9-dihydroxy-7-methyl-1-(phenylsulfinyl)-spirononane-3,2'-<1,3>dioxolane> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 925-90-6
ethylmagnesium bromide

: 145095-35-8
6-hydroxy-7-methyl-1-(phenylsulfinyl)spirononane-3,2'-<1,3>dioxolane>-9-one

: 145095-38-1
9-ethyl-6,9-dihydroxy-7-methyl-1-(phenylsulfinyl)-spirononane-3,2'-<1,3>dioxolane>

Guidance literature:: With chloro-trimethyl-silane; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.25h;
DOI:10.1080/00397919208021662

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 145095-38-1
9-ethyl-6,9-dihydroxy-7-methyl-1-(phenylsulfinyl)-spirononane-3,2'-<1,3>dioxolane>

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium tetramethylpiperidide (LiTMP), HMPA / 1.) THF, hexane, from -40 deg C to RT, 2 h, 2.) THF, hexane, a) -15 deg C, b) RT, 8 h

2: 69 percent / MCPBA / CH₂Cl₂ / 0.5 h / 0 °C

3: 91 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / acetonitrile / 0.5 h

4: 100 percent / TMSCl / tetrahydrofuran; diethyl ether / 0.25 h / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; chloro-trimethyl-silane; 2,2,6,6-tetramethylpiperidinyl-lithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1080/00397919208021662

Reference yield:

: 129012-81-3
7-(phenylsulfinyl)-1,4-dioxaspiro<4.5>decan-8-one

: 145095-38-1
9-ethyl-6,9-dihydroxy-7-methyl-1-(phenylsulfinyl)-spirononane-3,2'-<1,3>dioxolane>

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / acetonitrile / 0.5 h

2: 100 percent / TMSCl / tetrahydrofuran; diethyl ether / 0.25 h / -78 °C

With chloro-trimethyl-silane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1080/00397919208021662