(S)-benzyl 3-((S)-2-amino-2-cyclohexyl-N-methylacetamido)piperidine-1-carboxylate hydrochloride

Base Information

Chemical Name:(S)-benzyl 3-((S)-2-amino-2-cyclohexyl-N-methylacetamido)piperidine-1-carboxylate hydrochloride
CAS No.:1361323-16-1
Molecular Formula:C₂₂H₃₃N₃O₃*ClH
Molecular Weight:423.983
Hs Code.:

Synonyms:(S)-benzyl 3-((S)-2-amino-2-cyclohexyl-N-methylacetamido)piperidine-1-carboxylate hydrochloride

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Chemical Property of (S)-benzyl 3-((S)-2-amino-2-cyclohexyl-N-methylacetamido)piperidine-1-carboxylate hydrochloride

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Technology Process of (S)-benzyl 3-((S)-2-amino-2-cyclohexyl-N-methylacetamido)piperidine-1-carboxylate hydrochloride

There total 6 articles about (S)-benzyl 3-((S)-2-amino-2-cyclohexyl-N-methylacetamido)piperidine-1-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361323-15-0
(S)-benzyl 3-((S)-2-(tert-butoxycarbonylamino)-2-cyclohexyl-N-methylacetamido)piperidine-1-carboxylate

: 1361323-16-1
(S)-benzyl 3-((S)-2-amino-2-cyclohexyl-N-methylacetamido)piperidine-1-carboxylate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 876379-22-5
benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate

: 1361323-16-1
(S)-benzyl 3-((S)-2-amino-2-cyclohexyl-N-methylacetamido)piperidine-1-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 0 - 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 1361323-13-8
(S)-benzyl 3-(methylamino)piperidine-1-carboxylate hydrochloride

: 1361323-16-1
(S)-benzyl 3-((S)-2-amino-2-cyclohexyl-N-methylacetamido)piperidine-1-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.109