2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yl)propan-2-ol

Base Information

Chemical Name:2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yl)propan-2-ol
CAS No.:1415794-26-1
Molecular Formula:C₂₀H₃₂BNO₃
Molecular Weight:345.29
Hs Code.:

Synonyms:2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yl)propan-2-ol

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Chemical Property of 2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yl)propan-2-ol

Chemical Property:

Boiling Point:477.0±20.0 °C(Predicted)
Density:1.07±0.1 g/cm3(Predicted)

Purity/Quality:

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Technology Process of 2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yl)propan-2-ol

There total 5 articles about 2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1415794-26-1
2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yl)propan-2-ol

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); triethylamine; In 1,4-dioxane; at 110 ℃; for 6.5h; Inert atmosphere;

Reference yield:

: 1415794-25-0
2-(1-(4-bromophenyl)piperidin-4-yl)propan-2-ol

: 73183-34-3
bis(pinacol)diborane

: 1415794-26-1
2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yl)propan-2-ol

Guidance literature:: 2-(1-(4-bromophenyl)piperidin-4-yl)propan-2-ol; bis(pinacol)diborane; With potassium acetate; In dimethyl sulfoxide; for 0.5h;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 70 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1415794-24-9
ethyl 1-(4-bromophenyl)piperidine-4-carboxylate

: 1415794-26-1
2-(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran; diethyl ether / 20 °C / Inert atmosphere; Cooling with ice

2.1: potassium acetate / dimethyl sulfoxide / 0.5 h

2.2: 20 h / 70 °C / Inert atmosphere

With potassium acetate; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;