1-hydroxy-2-naphthyl cyclohexyl ketone

Base Information

• Chemical Name: 1-hydroxy-2-naphthyl cyclohexyl ketone
• CAS No.: 17735-20-5
• Molecular Formula: C₁₇H₁₈O₂
• Molecular Weight: 254.329
• Mol file: 17735-20-5.mol

Synonyms:1-hydroxy-2-naphthyl cyclohexyl ketone

Chemical Property of 1-hydroxy-2-naphthyl cyclohexyl ketone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-hydroxy-2-naphthyl cyclohexyl ketone

There total 10 articles about 1-hydroxy-2-naphthyl cyclohexyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

α-naphthol (90-15-3) + cyclohexanylcarbonyl chloride (2719-27-9) → 1-hydroxy-2-naphthyl cyclohexyl ketone (17735-20-5)

Guidance literature:

With hafnium(IV) trifluoromethanesulfonate; In nitromethane; toluene; at 100 ℃; for 6h;

DOI:10.1016/0040-4039(96)00216-X

Reference yield: 82.0%

1-naphthyl cyclohexylcarboxylate (18731-61-8) → 1-hydroxy-2-naphthyl cyclohexyl ketone (17735-20-5)

Guidance literature:

With hafnium(IV) trifluoromethanesulfonate; In nitromethane; toluene; at 100 ℃; for 6h;

DOI:10.1016/0040-4039(96)00216-X

Reference yield: 40.0%

α-naphthol (90-15-3) + cyclohexanecarbaldehyde (2043-61-0) → 1-hydroxy-2-naphthyl cyclohexyl ketone (17735-20-5)

Guidance literature:

With [(C₆H₆)(PCy₃)(CO)RuH]⁺*BF₄^?; potassium carbonate; triphenylphosphine; In chlorobenzene; at 110 ℃; for 8h; regioselective reaction; Schlenk technique;

DOI:10.1002/ejoc.201403518

upstream raw materials:

α-naphthol

Cyclohexanecarboxylic acid

1-naphthyl cyclohexylcarboxylate

cyclohexanylcarbonyl chloride