2'-(4-fluorophenyl)-11β-hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-eno[3,2-c]pyrazole

Base Information

Chemical Name:2'-(4-fluorophenyl)-11β-hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-eno[3,2-c]pyrazole
CAS No.:69607-31-4
Molecular Formula:C₃₀H₃₅FN₂O₅
Molecular Weight:522.617
Hs Code.:

Synonyms:2'-(4-fluorophenyl)-11β-hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-eno[3,2-c]pyrazole

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Chemical Property of 2'-(4-fluorophenyl)-11β-hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-eno[3,2-c]pyrazole

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Technology Process of 2'-(4-fluorophenyl)-11β-hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-eno[3,2-c]pyrazole

There total 3 articles about 2'-(4-fluorophenyl)-11β-hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-eno[3,2-c]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 11β-hydroxy-2-hydroxymethylene-17,20:20.21-bis(methylenedioxy)-prepn-4-ene-3-one

: 69607-31-4
2'-(4-fluorophenyl)-11β-hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-eno[3,2-c]pyrazole

Guidance literature:: With sodium acetate; In water; acetic acid; at 20 ℃;
DOI:10.1016/S0039-128X(02)00171-X

Reference yield:

: C₂₆H₃₆O₈

: (4-fluoro-phenyl)-hydrazine hydrochloride

: 3113-48-2
C₂₄H₃₂O₇

: 1258527-87-5
C₃₂H₃₉FN₂O₆

: 69607-31-4
2'-(4-fluorophenyl)-11β-hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-eno[3,2-c]pyrazole

Guidance literature:: With sodium acetate; acetic acid; In water; at 20 ℃; for 7h;

Reference yield:

: 50-23-7
HYDROCORTISONE

: 69607-31-4
2'-(4-fluorophenyl)-11β-hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-eno[3,2-c]pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 3 h / 20 °C

1.2: 60 percent / NaH / toluene / 4 h / 20 °C

2.1: 84 percent / NaOAc / acetic acid; H₂O / 20 °C

With sodium acetate; In dichloromethane; water; acetic acid;
DOI:10.1016/S0039-128X(02)00171-X