Technology Process of 4-(2-hydroxy-3,4-dimethoxyphenyl)butanoic acid
There total 2 articles about 4-(2-hydroxy-3,4-dimethoxyphenyl)butanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
acetic acid;
at 64 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) aluminium chloride, 2.) sodium dithionite, sodium hydroxide / 1.) 1,1,2,2-tetrachloroethane, room temperature, 16 h, steam-bath, 2 h, 2.) methanol, water, room temperature, 21 h, reflux 24 h
2: 77 percent / hydrogen / 10percent palladium-carbon / acetic acid / 4 h / 64 °C
With
sodium hydroxide; aluminium trichloride; sodium dithionite; hydrogen;
palladium on activated charcoal;
In
acetic acid;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: H2SO4 / Heating
2: 91 percent / potassium carbonate / acetone / 48 h / Heating
3: 100 percent / lithium aluminium hydride / diethyl ether / 2 h / Heating
4: 88 percent / pyridine / 1.) 0 deg C, 3 h, 2.) -5 deg C, 24 h
5: 89 percent / lithium bromide / acetone / 24 h / Ambient temperature
6: 42 percent / Mg, 3-(4-benzyloxyphenyl)propanal / tetrahydrofuran / 18 h / Ambient temperature
7: 75 percent / pyridinium chlorochromate / CH2Cl2
8: hydrogen / 5percent palladium-carbon / acetic acid
With
pyridine; lithium aluminium tetrahydride; sulfuric acid; hydrogen; 3-(4-(benzyloxy)phenyl)propanal; potassium carbonate; magnesium; pyridinium chlorochromate; lithium bromide;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dichloromethane; acetic acid; acetone;
