1-(4-hydroxyphenyl)-7-(2-hydroxy-3,4-dimethoxyphenyl)heptan-3-one

Base Information

• Chemical Name: 1-(4-hydroxyphenyl)-7-(2-hydroxy-3,4-dimethoxyphenyl)heptan-3-one
• CAS No.: 68486-81-7
• Molecular Formula: C₂₁H₂₆O₅
• Molecular Weight: 358.434
• Mol file: 68486-81-7.mol

Synonyms:1-(4-hydroxyphenyl)-7-(2-hydroxy-3,4-dimethoxyphenyl)heptan-3-one

Chemical Property of 1-(4-hydroxyphenyl)-7-(2-hydroxy-3,4-dimethoxyphenyl)heptan-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-hydroxyphenyl)-7-(2-hydroxy-3,4-dimethoxyphenyl)heptan-3-one

There total 12 articles about 1-(4-hydroxyphenyl)-7-(2-hydroxy-3,4-dimethoxyphenyl)heptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-(4-benzyloxyphenyl)-7-(2-benzyloxy-3,4-dimethoxyphenyl)heptan-3-one (68486-79-3) → 1-(4-hydroxyphenyl)-7-(2-hydroxy-3,4-dimethoxyphenyl)heptan-3-one (68486-81-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid;

Reference yield: 22.0%

1-(4-benzyloxy-3-iodophenyl)-7-(2-benzyloxy-3,4-dimethoxy-5-iodophenyl)heptan-3-one (68486-87-3) → dibenzylmyricanone (68486-84-0) + 1-(4-hydroxyphenyl)-7-(2-hydroxy-3,4-dimethoxyphenyl)heptan-3-one (68486-81-7)

Guidance literature:

With bis(triphenylphosphine)nickel(II) chloride; triphenylphosphine; zinc; In N,N-dimethyl-formamide; at 64 ℃; for 72h;

Reference yield:

1,2,3-trimethoxybenzene (634-36-6) → 1-(4-hydroxyphenyl)-7-(2-hydroxy-3,4-dimethoxyphenyl)heptan-3-one (68486-81-7)

Guidance literature:

Multi-step reaction with 10 steps

1: 1.) aluminium chloride, 2.) sodium dithionite, sodium hydroxide / 1.) 1,1,2,2-tetrachloroethane, room temperature, 16 h, steam-bath, 2 h, 2.) methanol, water, room temperature, 21 h, reflux 24 h

2: 77 percent / hydrogen / 10percent palladium-carbon / acetic acid / 4 h / 64 °C

3: H₂SO₄ / Heating

4: 91 percent / potassium carbonate / acetone / 48 h / Heating

5: 100 percent / lithium aluminium hydride / diethyl ether / 2 h / Heating

6: 88 percent / pyridine / 1.) 0 deg C, 3 h, 2.) -5 deg C, 24 h

7: 89 percent / lithium bromide / acetone / 24 h / Ambient temperature

8: 42 percent / Mg, 3-(4-benzyloxyphenyl)propanal / tetrahydrofuran / 18 h / Ambient temperature

9: 75 percent / pyridinium chlorochromate / CH₂Cl₂

10: hydrogen / 5percent palladium-carbon / acetic acid

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; sodium dithionite; sulfuric acid; hydrogen; 3-(4-(benzyloxy)phenyl)propanal; potassium carbonate; magnesium; pyridinium chlorochromate; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; acetic acid; acetone;

upstream raw materials:

1-(4-benzyloxyphenyl)-7-(2-benzyloxy-3,4-dimethoxyphenyl)heptan-3-one

1-(4-benzyloxy-3-iodophenyl)-7-(2-benzyloxy-3,4-dimethoxy-5-iodophenyl)heptan-3-one

1,2,3-trimethoxybenzene

4-(2-hydroxy-3,4-dimethoxyphenyl)butanoic acid