C₄₈H₅₃NO₁₄

Base Information

• Chemical Name: C₄₈H₅₃NO₁₄
• CAS No.: 849213-08-7
• Molecular Formula: C₄₈H₅₃NO₁₄
• Molecular Weight: 867.947
• Mol file: 849213-08-7.mol

Synonyms:C₄₈H₅₃NO₁₄

Chemical Property of C₄₈H₅₃NO₁₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₅₃NO₁₄

There total 8 articles about C₄₈H₅₃NO₁₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C54H67NO14Si (849213-07-6) → C48H53NO14 (849213-08-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

Reference yield:

taxol (33069-62-4) → C48H53NO14 (849213-08-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C

2: hydrazine / Isopropyl acetate / 1 h / 20 °C

3: dmap / dichloromethane / 3 h / 20 °C

4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 22 h / 20 °C

5: sodium tetrahydroborate / methanol; ethanol / 5 h / 0 °C

6: dmap / dichloromethane / 15 h / 20 °C

7: hydrogen fluoride / water; acetonitrile / 0.83 h / 0 °C

8: toluene-4-sulfonic acid / dichloromethane / 1.5 h / 20 °C

9: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; tetrapropylammonium perruthennate; hydrogen fluoride; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane; Isopropyl acetate; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

2'-O-TBDMS-7-O-TES-9,10-diketo-paclitaxel (162664-54-2) → C48H53NO14 (849213-08-7)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol; ethanol / 5 h / 0 °C

2: 4-pyrrolidin-1-ylpyridine; triethylamine / dichloromethane / 15 h / 20 °C

3: hydrogen fluoride / water; acetonitrile / 0.83 h / 0 °C

4: toluene-4-sulfonic acid / dichloromethane / 1.5 h / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; hydrogen fluoride; tetrabutyl ammonium fluoride; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;

upstream raw materials:

C₅₄H₆₇NO₁₄Si

2-O-TBDMS-9-α-OH-9-desoxo-10-epi-paclitaxel

taxol

2'-O-(tert-butyldimethylsilyl)paclitaxel