162664-54-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 148121-24-8 10-deacetoxy-paclitaxel 
• 149705-85-1 7-deoxypaclitaxel 
• 33069-62-4 taxol 
• 114655-02-6 2'-O-(tert-butyldimethylsilyl)paclitaxel 
• 162375-26-0 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel 
• 78432-77-6 10-deacetylpaclitaxel 
• 994-30-9 triethylsilyl chloride 
• 162809-97-4 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel 

Downstream Products

• 204981-02-2 C₅₈H₇₇NO₁₃Si₂ 
• 204981-03-3 C₅₂H₆₃NO₁₃Si 
• 204981-05-5 C₅₄H₆₇NO₁₄Si 
• 204981-04-4 C₅₄H₆₇NO₁₃SSi 
• 849213-03-2 2-O-TBDMS-9-α-OH-9-desoxo-10-epi-paclitaxel 
• 1051405-78-7 C₃₉H₄₆O₁₂ 
• 1051405-72-1 C₄₇H₅₃NO₁₄ 
• 1051405-75-4 C₅₅H₅₉NO₁₅ 
• 1052091-65-2 C₆₂H₇₁NO₁₇ 
• 849342-14-9 C₆₂H₇₁NO₁₇ 
• 849213-05-4 2-O-TES-7-O-methylthiomethyl-9-α-OH-10-epi-paclitaxel 
• 849213-04-3 2'-O-TES-9-α-OH-10-epi-paclitaxel 

Relevant academic research and scientific papers

BIOLOGICALLY ACTIVE TAXANE ANALOGS AND METHODS OF TREATMENT BY ORAL ADMINISTRATION

The present invention relates to a novel chemical compound of formula S-(I) for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

TAXANE ANALOGS FOR THE TREATMENT OF BRAIN CANCER

Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a s

Biologically Active Taxane Analogs and Methods of Treatment

The present application relates to new taxane analogs, pharmaceutical compositions comprising such analogs and methods of treating cancer comprising such compositions. The compounds according to the present application have the general formula: wherein R

9,10-alpha,alpha-OH-TAXANE ANALOGS AND METHODS FOR PRODUCTION THEREOF

The present invention relates to new taxane analogs useful for the treatment of cancer as well as methods for producing the same. The chemical compounds according to the present invention have the general Formula (I) wherein R1 and R2 are each selected fr

Synthesis of a novel C-10 spiro-epoxide of paclitaxel

New analogues of paclitaxel (1a, active constituent of Taxol) were synthesized containing an epoxide at the C-10 position. The introduction of the epoxide was carried out by selective removal of the C10-acetate followed by protection of the C2′- and C7-hydroxyl groups. After oxidation to yield a ketone at the C10-position, this intermediate was reacted with dimethylsulfonium ylide. Deprotection and further manipulations provide the C10-spiro epoxide of paclitaxel (1b) and the corresponding C7-MOM ether (1c).

The chemistry of the taxane diterpene: Stereoselective reductions of taxanes

Stereoselective reductions of taxanes are detailed. Chelation- controlled reductions employing SmI2 are described for the stereoselective reduction of the 9-keto functionality of the diterpene moiety of several taxanes. In all cases the 9β-hydr

Syntheses of Novel C-9 and C-10 Modified Bioactive Taxanes

A method has been developed for the syntheses of hitherto unreported C-9 and C-10 modified taxanes.These analogs demonstrated excellent to good cytotoxicity against B 16 melanoma cells.