162664-54-2

Basic information

• Product Name: 2'-O-TBDMS-7-O-TES-9,10-diketo-paclitaxel
• Synonyms: 2'-O-TBDMS-7-O-TES-9,10-diketo-paclitaxel
• CAS NO: 162664-54-2
• Molecular Weight: 1038.39
• Mol File: 162664-54-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2'-O-TBDMS-7-O-TES-9,10-diketo-paclitaxel(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-O-TBDMS-7-O-TES-9,10-diketo-paclitaxel(162664-54-2)
• EPA Substance Registry System: 2'-O-TBDMS-7-O-TES-9,10-diketo-paclitaxel(162664-54-2)

Safety Data

• Hazardous Substances Data: 162664-54-2(Hazardous Substances Data)

Upstream product

• 114655-02-6 2'-O-(tert-butyldimethylsilyl)paclitaxel 
• 33069-62-4 taxol 
• 994-30-9 triethylsilyl chloride 
• 149705-85-1 7-deoxypaclitaxel 
• 148121-24-8 10-deacetoxy-paclitaxel 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 162809-97-4 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel 
• 162375-26-0 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel 
• 78432-77-6 10-deacetylpaclitaxel 

Downstream Products

• 162664-55-3 2'-TBS-10-deacetyl-7-TES-10α-hydroxypaclitaxel 
• 204981-02-2 C₅₈H₇₇NO₁₃Si₂ 
• 204981-03-3 C₅₂H₆₃NO₁₃Si 
• 204981-05-5 C₅₄H₆₇NO₁₄Si 
• 204981-04-4 C₅₄H₆₇NO₁₃SSi 
• 162664-56-4 2'-O-TBDMS-7-O-TES-9,10-α,α-OH-9-desoxo-10-deacetylpaclitaxel 
• 162664-58-6 2'-TBS-10-deacetyl-7-TES-9α-hydroxy-10-ketopaclitaxel 
• 162664-57-5 2'-O-TBDMS-7-O-TES-9-α-OH-9-desoxo-10-epi-paclitaxel 
• 162809-92-9 2'-TBS-10-epi-7-TES-paclitaxel 
• 162809-94-1 10-deacetylpaclitaxel 
• 162809-96-3 9-α-OH-9-desoxo-10-epipaclitaxel 
• 162809-93-0 10-epi-paclitaxel 
• 849213-03-2 2-O-TBDMS-9-α-OH-9-desoxo-10-epi-paclitaxel 
• 1051405-78-7 C₃₉H₄₆O₁₂ 

Relevant articles and documents

BIOLOGICALLY ACTIVE TAXANE ANALOGS AND METHODS OF TREATMENT BY ORAL ADMINISTRATION

The present invention relates to a novel chemical compound of formula S-(I) for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

Biologically Active Taxane Analogs and Methods of Treatment

The present application relates to new taxane analogs, pharmaceutical compositions comprising such analogs and methods of treating cancer comprising such compositions. The compounds according to the present application have the general formula: wherein R

Synthesis of a novel C-10 spiro-epoxide of paclitaxel

New analogues of paclitaxel (1a, active constituent of Taxol) were synthesized containing an epoxide at the C-10 position. The introduction of the epoxide was carried out by selective removal of the C10-acetate followed by protection of the C2′- and C7-hydroxyl groups. After oxidation to yield a ketone at the C10-position, this intermediate was reacted with dimethylsulfonium ylide. Deprotection and further manipulations provide the C10-spiro epoxide of paclitaxel (1b) and the corresponding C7-MOM ether (1c).