4-(5-(4-(bis(4-tert-butylphenyl)amino)phenyl)thiophen-2-yl)benzaldehyde

Base Information

Chemical Name:4-(5-(4-(bis(4-tert-butylphenyl)amino)phenyl)thiophen-2-yl)benzaldehyde
CAS No.:1370333-07-5
Molecular Formula:C₃₇H₃₇NOS
Molecular Weight:543.773
Hs Code.:

Synonyms:4-(5-(4-(bis(4-tert-butylphenyl)amino)phenyl)thiophen-2-yl)benzaldehyde

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Chemical Property of 4-(5-(4-(bis(4-tert-butylphenyl)amino)phenyl)thiophen-2-yl)benzaldehyde

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Technology Process of 4-(5-(4-(bis(4-tert-butylphenyl)amino)phenyl)thiophen-2-yl)benzaldehyde

There total 4 articles about 4-(5-(4-(bis(4-tert-butylphenyl)amino)phenyl)thiophen-2-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1370333-06-4
(N,N-di-tert-butylphenyl)-4-(thiophen-2-yl)aniline

: 1122-91-4
4-bromo-benzaldehyde

: 1370333-07-5
4-(5-(4-(bis(4-tert-butylphenyl)amino)phenyl)thiophen-2-yl)benzaldehyde

Guidance literature:: (N,N-di-tert-butylphenyl)-4-(thiophen-2-yl)aniline; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -40 ℃; for 0.5h; Inert atmosphere;

With tributyltin chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

4-bromo-benzaldehyde; With bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 90 ℃; for 24h; Inert atmosphere;
DOI:10.1002/asia.201100777

Reference yield:

: 70010-48-9
1-(2-thienyl)-4-aminobenzene

: 1370333-07-5
4-(5-(4-(bis(4-tert-butylphenyl)amino)phenyl)thiophen-2-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / toluene / 15 h / 90 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -40 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

2.3: 24 h / 90 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; sodium t-butanolate; In tetrahydrofuran; hexane; toluene; 1.1: Buchwald-Hartwig coupling / 2.3: Stille coupling;
DOI:10.1002/asia.201100777

Reference yield:

: 59156-21-7
2-(4-nitrophenyl)thiophene

: 1370333-07-5
4-(5-(4-(bis(4-tert-butylphenyl)amino)phenyl)thiophen-2-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; tin(II) chloride dihdyrate / ethanol / Inert atmosphere; Reflux

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / toluene / 15 h / 90 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -40 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

3.3: 24 h / 90 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; tin(II) chloride dihdyrate; sodium t-butanolate; In tetrahydrofuran; ethanol; hexane; toluene; 2.1: Buchwald-Hartwig coupling / 3.3: Stille coupling;
DOI:10.1002/asia.201100777