3-[4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio]propane-1,2-diol

Base Information

• Chemical Name: 3-[4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio]propane-1,2-diol
• CAS No.: 1229571-88-3
• Molecular Formula: C₁₇H₁₅F₂N₃O₂S
• Molecular Weight: 363.388
• Mol file: 1229571-88-3.mol

Synonyms:3-[4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio]propane-1,2-diol

Chemical Property of 3-[4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio]propane-1,2-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio]propane-1,2-diol

There total 6 articles about 3-[4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio]propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-bromo-2,3-propanediol (4704-77-2) + 4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione (581098-38-6) → 3-[4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio]propane-1,2-diol (1229571-88-3)

Guidance literature:

With sodium ethanolate; In methanol; at 20 ℃; for 16h;

DOI:10.1021/jm100161q

Reference yield:

1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)ethan-1-one (302839-09-4) → 3-[4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio]propane-1,2-diol (1229571-88-3)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid; sodium nitrite / water / 0.5 h / 10 - 20 °C

2: palladium 10% on activated carbon; hydrogen; hydrogenchloride / isopropyl alcohol

3: methanol / 1.5 h / Reflux

4: sodium ethanolate / methanol / 16 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium ethanolate; acetic acid; sodium nitrite; In methanol; water; isopropyl alcohol;

DOI:10.1039/c5ob01505g

Reference yield:

1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)-2-(hydroxyimino)-ethan-1-one (457081-00-4) → 3-[4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio]propane-1,2-diol (1229571-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen; hydrogenchloride / isopropyl alcohol

2: methanol / 1.5 h / Reflux

3: sodium ethanolate / methanol / 16 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium ethanolate; In methanol; isopropyl alcohol;

DOI:10.1039/c5ob01505g

upstream raw materials:

1-bromo-2,3-propanediol

4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione

1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)ethan-1-one

1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)-2-(hydroxyimino)-ethan-1-one

Downstream raw materials:

4-(4-fluorophenyl)-5-{2-[(1R,4R)-4-hydroxycyclohexylamino]pyridin-4-yl}-1,3-dihydroimidazol-2-one

4-(4-fluorophenyl)-5-[2-(1-phenylethylamino)pyridin-4-yl]-1,3-dihydroimidazol-2-one

3-((4-(4-fluorophenyl)-5-(2-((1-phenylethyl)amino)pyridin-4-yl)-1Himidazol-2-yl)thio)propane-1,2-diol

3-((4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridin-4-yl)-1H-imidazol-2-yl)thio)propane-1,2-diol