3-((4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridin-4-yl)-1H-imidazol-2-yl)thio)propane-1,2-diol

Base Information

• Chemical Name: 3-((4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridin-4-yl)-1H-imidazol-2-yl)thio)propane-1,2-diol
• CAS No.: 1012305-64-4
• Molecular Formula: C₂₂H₂₇FN₄O₂S
• Molecular Weight: 430.546
• Mol file: 1012305-64-4.mol

Synonyms:3-((4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridin-4-yl)-1H-imidazol-2-yl)thio)propane-1,2-diol

Chemical Property of 3-((4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridin-4-yl)-1H-imidazol-2-yl)thio)propane-1,2-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridin-4-yl)-1H-imidazol-2-yl)thio)propane-1,2-diol

There total 18 articles about 3-((4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridin-4-yl)-1H-imidazol-2-yl)thio)propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-(2-(((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)thio)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-N-(3-methylbutan-2-yl)pyridin-2-amine → 3-((4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridin-4-yl)-1H-imidazol-2-yl)thio)propane-1,2-diol (1012305-64-4)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 3h;

DOI:10.1039/c5ob01505g

Reference yield: 41.0%

1-bromo-2,3-propanediol (4704-77-2) + 4-(4-fluorophenyl)-5-(2-(3-methylbutan-2-ylamino)pyridin-4-yl)-1,3-dihydroimidazol-2-thione (1012305-56-4) → 3-((4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridin-4-yl)-1H-imidazol-2-yl)thio)propane-1,2-diol (1012305-64-4)

Guidance literature:

With potassium tert-butylate; In methanol; for 3h; Inert atmosphere; Reflux;

DOI:10.1021/jm800373t

Reference yield:

4-(4-fluorophenyl)-5-(2-(3-methylbutan-2-ylamino)pyridin-4-yl)-1,3-dihydroimidazol-2-thione (1012305-56-4) → 3-((4-(4-fluorophenyl)-5-(2-((3-methylbutan-2-yl)amino)pyridin-4-yl)-1H-imidazol-2-yl)thio)propane-1,2-diol (1012305-64-4)

Guidance literature:

With potassium tert-butylate; In methanol; Inert atmosphere; Heating;

DOI:10.1039/b717605h

upstream raw materials:

4-(4-fluorophenyl)-5-(2-(3-methylbutan-2-ylamino)pyridin-4-yl)-1,3-dihydroimidazol-2-thione

1-bromo-2,3-propanediol

3-[4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1H-imidazol-2-ylthio]propane-1,2-diol

4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione