1-[4-(4-chlorobenzenesulfonylamino)butyl]-6-(2-hydroxy-1-hydroxymethyl)ethylazulene

Base Information

Chemical Name:1-[4-(4-chlorobenzenesulfonylamino)butyl]-6-(2-hydroxy-1-hydroxymethyl)ethylazulene
CAS No.:178871-22-2
Molecular Formula:C₂₃H₂₆ClNO₄S
Molecular Weight:447.983
Hs Code.:

Synonyms:1-[4-(4-chlorobenzenesulfonylamino)butyl]-6-(2-hydroxy-1-hydroxymethyl)ethylazulene

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Chemical Property of 1-[4-(4-chlorobenzenesulfonylamino)butyl]-6-(2-hydroxy-1-hydroxymethyl)ethylazulene

Chemical Property:

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Technology Process of 1-[4-(4-chlorobenzenesulfonylamino)butyl]-6-(2-hydroxy-1-hydroxymethyl)ethylazulene

There total 7 articles about 1-[4-(4-chlorobenzenesulfonylamino)butyl]-6-(2-hydroxy-1-hydroxymethyl)ethylazulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 178871-19-7
3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(2-hydroxy-1-hydroxymethyl-ethyl)-azulene-1-carboxylic acid methyl ester

: 178871-22-2
1-[4-(4-chlorobenzenesulfonylamino)butyl]-6-(2-hydroxy-1-hydroxymethyl)ethylazulene

Guidance literature:: With phosphoric acid; at 110 ℃; for 0.166667h;
DOI:10.1016/0968-0896(96)00038-7

Reference yield:

: 178870-61-6
3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(1-hydroxy-1-methyl-ethyl)-azulene-1-carboxylic acid methyl ester

: 178871-22-2
1-[4-(4-chlorobenzenesulfonylamino)butyl]-6-(2-hydroxy-1-hydroxymethyl)ethylazulene

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / p-TsOH / benzene / 0.33 h / Heating

2: 85 percent / OsO₄, N-methylmorpholine N-oxide*2H₂O / tetrahydrofuran; 2-methyl-propan-2-ol / 18 h / Ambient temperature

3: 96 percent / Et₃N, DMAP / tetrahydrofuran / 2 h / Ambient temperature

4: 79 percent / p-TsOH / benzene / 0.33 h / Heating

5: 1.) BH₃*THF, 2.) 6N aq. NaOH, 30percent aq. H₂O₂ / 1.) 0 deg C, 3 h, 2.) RT, 1 h

6: K₂CO₃ / methanol / 2 h / Ambient temperature

7: 80 percent / 100percent phosphoric acid / 0.17 h / 110 °C

With dmap; sodium hydroxide; osmium(VIII) oxide; borane-THF; phosphoric acid; dihydrogen peroxide; potassium carbonate; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; tert-butyl alcohol; benzene;
DOI:10.1016/0968-0896(96)00038-7

Reference yield:

: 178870-67-2
3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-isopropenyl-azulene-1-carboxylic acid methyl ester

: 178871-22-2
1-[4-(4-chlorobenzenesulfonylamino)butyl]-6-(2-hydroxy-1-hydroxymethyl)ethylazulene

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / OsO₄, N-methylmorpholine N-oxide*2H₂O / tetrahydrofuran; 2-methyl-propan-2-ol / 18 h / Ambient temperature

2: 96 percent / Et₃N, DMAP / tetrahydrofuran / 2 h / Ambient temperature

3: 79 percent / p-TsOH / benzene / 0.33 h / Heating

4: 1.) BH₃*THF, 2.) 6N aq. NaOH, 30percent aq. H₂O₂ / 1.) 0 deg C, 3 h, 2.) RT, 1 h

5: K₂CO₃ / methanol / 2 h / Ambient temperature

6: 80 percent / 100percent phosphoric acid / 0.17 h / 110 °C

With dmap; sodium hydroxide; osmium(VIII) oxide; borane-THF; phosphoric acid; dihydrogen peroxide; potassium carbonate; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; tert-butyl alcohol; benzene;
DOI:10.1016/0968-0896(96)00038-7