Technology Process of 1,1-dimethylethyl [(1S)-2-azido-1-(cyclohexylmethyl)ethyl]methylcarbamate
There total 5 articles about 1,1-dimethylethyl [(1S)-2-azido-1-(cyclohexylmethyl)ethyl]methylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-tert-butyl (1-azido-3-cyclohexylpropan-2-yl)carbamate;
With
sodium hydride;
In
N,N-dimethyl-formamide;
methyl iodide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 0.83 h / 0 - 20 °C
2.1: sodium azide / N,N-dimethyl-formamide / 80 °C
3.1: sodium hydride / N,N-dimethyl-formamide
3.2: 1.5 h / 20 °C
With
sodium azide; sodium hydride; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 0 - 20 °C
2.1: triethylamine / dichloromethane / 0.83 h / 0 - 20 °C
3.1: sodium azide / N,N-dimethyl-formamide / 80 °C
4.1: sodium hydride / N,N-dimethyl-formamide
4.2: 1.5 h / 20 °C
With
sodium azide; sodium hydride; sodium hydrogencarbonate; triethylamine;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
