Technology Process of 12-methoxy-1,5,9-tris(p-tolylsulfonyl)-1,5,9-triazacyclotetradecane
There total 5 articles about 12-methoxy-1,5,9-tris(p-tolylsulfonyl)-1,5,9-triazacyclotetradecane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) Cs2CO3 / 1.) DMF, 100 deg C, 3 h, 2.) DMF
2: 96 percent / 69percent aq. HClO4 / CH2Cl2 / 2 h / Ambient temperature
3: 91 percent / NaBH4 / ethanol / 15 h / Ambient temperature
4: 1.) NaH, imidazole / 1.) THF, reflux, 2 h, 2.) THF, reflux, 3 h
With
1H-imidazole; sodium tetrahydroborate; perchloric acid; sodium hydride; caesium carbonate;
In
ethanol; dichloromethane;
DOI:10.1021/ja00125a005
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) Cs2CO3 / 1.) DMF, 100 deg C, 3 h, 2.) DMF
2: 96 percent / 69percent aq. HClO4 / CH2Cl2 / 2 h / Ambient temperature
3: 91 percent / NaBH4 / ethanol / 15 h / Ambient temperature
4: 1.) NaH, imidazole / 1.) THF, reflux, 2 h, 2.) THF, reflux, 3 h
With
1H-imidazole; sodium tetrahydroborate; perchloric acid; sodium hydride; caesium carbonate;
In
ethanol; dichloromethane;
DOI:10.1021/ja00125a005
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 91 percent / NaBH4 / ethanol / 15 h / Ambient temperature
2: 1.) NaH, imidazole / 1.) THF, reflux, 2 h, 2.) THF, reflux, 3 h
With
1H-imidazole; sodium tetrahydroborate; sodium hydride;
In
ethanol;
DOI:10.1021/ja00125a005
