C₂₁H₁₈F₂N₂O₃

Base Information

• Chemical Name: C₂₁H₁₈F₂N₂O₃
• CAS No.: 1001413-68-8
• Molecular Formula: C₂₁H₁₈F₂N₂O₃
• Molecular Weight: 384.382
• Mol file: 1001413-68-8.mol

Synonyms:C₂₁H₁₈F₂N₂O₃

Chemical Property of C₂₁H₁₈F₂N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₈F₂N₂O₃

There total 5 articles about C₂₁H₁₈F₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (1001413-01-9) + D-2-phenylglycinol (56613-80-0) → C21H18F2N2O3 (1001413-68-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2011.03.032

Reference yield:

C14H11F2NO3 (1001414-50-1) → C21H18F2N2O3 (1001413-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol / 60 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With sodium hydroxide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

Reference yield:

C15H13F2NO3 (1001412-63-0) → C21H18F2N2O3 (1001413-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / 60 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With sodium hydroxide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

upstream raw materials:

1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

D-2-phenylglycinol

C₁₄H₁₁F₂NO₃

C₁₅H₁₃F₂NO₃

Downstream raw materials:

(1-(3,4-difluorobenzyl)-2-oxo-N-{1(R)-2-[(2-oxo2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide)