5'-O-monomethoxytrityl-N-isobutyryldeoxyguanosine 3'-p-chlorophenylphosphonate

Base Information

• Chemical Name: 5'-O-monomethoxytrityl-N-isobutyryldeoxyguanosine 3'-p-chlorophenylphosphonate
• CAS No.: 76742-75-1
• Molecular Formula: C₄₀H₃₉ClN₅O₉P
• Molecular Weight: 800.205
• Mol file: 76742-75-1.mol

Synonyms:5'-O-monomethoxytrityl-N-isobutyryldeoxyguanosine 3'-p-chlorophenylphosphonate

Chemical Property of 5'-O-monomethoxytrityl-N-isobutyryldeoxyguanosine 3'-p-chlorophenylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-monomethoxytrityl-N-isobutyryldeoxyguanosine 3'-p-chlorophenylphosphonate

There total 3 articles about 5'-O-monomethoxytrityl-N-isobutyryldeoxyguanosine 3'-p-chlorophenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) → 5'-O-monomethoxytrityl-N-isobutyryldeoxyguanosine 3'-p-chlorophenylphosphonate (76742-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃

3: triisopropylbenzenesulfonyl chloride / 4 h

With triisopropylbenzenesulfonyl chloride; trichlorophosphate;

DOI:10.1016/S0040-4039(01)81907-9

Reference yield:

4-chlorophenylphosphorodichloridate (772-79-2) → 5'-O-monomethoxytrityl-N-isobutyryldeoxyguanosine 3'-p-chlorophenylphosphonate (76742-75-1)

Guidance literature:

Multi-step reaction with 2 steps

2: triisopropylbenzenesulfonyl chloride / 4 h

With triisopropylbenzenesulfonyl chloride;

DOI:10.1016/S0040-4039(01)81907-9

Reference yield:

4-chlorophenyl phosphate (13388-88-0) + N2-Isobutyryl-5'-O-monomethoxytrityl-2'-deoxyguanosine (59321-92-5) → 5'-O-monomethoxytrityl-N-isobutyryldeoxyguanosine 3'-p-chlorophenylphosphonate (76742-75-1)

Guidance literature:

With triisopropylbenzenesulfonyl chloride; for 4h; Yield given;

DOI:10.1016/S0040-4039(01)81907-9

upstream raw materials:

4-chlorophenyl phosphate

N²-Isobutyryl-5'-O-monomethoxytrityl-2'-deoxyguanosine

4-chloro-phenol

4-chlorophenylphosphorodichloridate

Downstream raw materials:

C₅₇H₅₅ClN₇O₁₄P

Phosphoric acid 4-chloro-phenyl ester 2-cyano-ethyl ester (2R,3S,5R)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

N²-isobutyryl-2'-deoxy-[3']guanylic acid 4-chloro-phenyl ester 2-cyano-ethyl ester