N²-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methylisocytidine 3'-O-(2-cyanoethyl phosphonate)

Base Information

• Chemical Name: N²-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methylisocytidine 3'-O-(2-cyanoethyl phosphonate)
• CAS No.: 207981-29-1
• Molecular Formula: C₄₁H₄₁N₄O₉P
• Molecular Weight: 764.772
• Mol file: 207981-29-1.mol

Synonyms:N²-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methylisocytidine 3'-O-(2-cyanoethyl phosphonate)

Chemical Property of N²-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methylisocytidine 3'-O-(2-cyanoethyl phosphonate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methylisocytidine 3'-O-(2-cyanoethyl phosphonate)

There total 1 articles about N²-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methylisocytidine 3'-O-(2-cyanoethyl phosphonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(2-benzoylamino-5-methyl-4-oxo-4H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester (148493-99-6) → N2-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methylisocytidine 3'-O-(2-cyanoethyl phosphonate) (207981-29-1)

Guidance literature:

With 1H-tetrazole; In acetonitrile; for 1.5h; Ambient temperature;

DOI:10.1002/hlca.19980810502

Reference yield: 56.0%

N2-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methylisocytidine 3'-O-(2-cyanoethyl phosphonate) (207981-29-1) → 5'-(dimethoxytrityl)-N-benzoyldeoxy-5-methylisocytidine (148493-98-5)

Guidance literature:

With potassium fluoride; In methanol; for 5h; Ambient temperature;

DOI:10.1002/hlca.19980810502

Reference yield:

N2-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methylisocytidine 3'-O-(2-cyanoethyl phosphonate) (207981-29-1) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methylisocytidine

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / 2M KF / methanol / 5 h / Ambient temperature

2: 54 percent / hydrazine monohydrate / pyridine / 5.75 h

With potassium fluoride; hydrazine hydrate; In pyridine; methanol;

DOI:10.1002/hlca.19980810502

upstream raw materials:

Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(2-benzoylamino-5-methyl-4-oxo-4H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Downstream raw materials:

5'-(dimethoxytrityl)-N-benzoyldeoxy-5-methylisocytidine