4-phenylhex-5-enoic acid

Base Information

• Chemical Name: 4-phenylhex-5-enoic acid
• CAS No.: 95838-21-4
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.242
• Mol file: 95838-21-4.mol

Synonyms:4-phenylhex-5-enoic acid

Chemical Property of 4-phenylhex-5-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-phenylhex-5-enoic acid

There total 3 articles about 4-phenylhex-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenyl-4-cyclohexanone (4894-75-1) → 4-phenylhex-5-enoic acid (95838-21-4)

Guidance literature:

1-phenyl-4-cyclohexanone; With dihydrogen peroxide; In methanol; water; at 25 ℃; for 3h;

With copper(ll) sulfate pentahydrate; iron(II) sulfate hexahydrate; In water; at 20 ℃;

DOI:10.1039/c9ob00750d

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + ethylmagnesium bromide (925-90-6) + Cinnamyl bromide (4392-24-9) → trans 6-phenyl-5-hexenoic acid (16424-56-9) + 4-phenylhex-5-enoic acid (95838-21-4)

Guidance literature:

ethylmagnesium bromide; With zirconocene dichloride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;

carbon dioxide; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.5h; under 760 Torr;

Cinnamyl bromide; With copper(l) iodide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 12h; Title compound not separated from byproducts;

DOI:10.1055/s-2005-864807

Reference yield:

2,3,4,7-tetrahydrooxepin-2-one (87256-39-1) + phenyllithium (591-51-5) → (Z)-6-Phenyl-hex-4-enoic acid (84565-04-8) + 4-phenylhex-5-enoic acid (95838-21-4)

Guidance literature:

With copper(l) iodide; Yield given. Multistep reaction. Yields of byproduct given; 1.) Et₂O; 2.) Et₂O, 0 deg C, 30 min;

DOI:10.1246/cl.1984.1795

upstream raw materials:

2,3,4,7-tetrahydrooxepin-2-one

phenyllithium

carbon dioxide

ethylmagnesium bromide

Downstream raw materials:

4-phenyl-5-hexen-1-ol

5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-pentanal