Trifluoro-methanesulfonic acid 2-(7,8-dimethoxy-phenanthren-1-yl)-5-methoxy-phenyl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid 2-(7,8-dimethoxy-phenanthren-1-yl)-5-methoxy-phenyl ester
• CAS No.: 172980-29-9
• Molecular Formula: C₂₄H₁₉F₃O₆S
• Molecular Weight: 492.472
• Mol file: 172980-29-9.mol

Synonyms:Trifluoro-methanesulfonic acid 2-(7,8-dimethoxy-phenanthren-1-yl)-5-methoxy-phenyl ester

Chemical Property of Trifluoro-methanesulfonic acid 2-(7,8-dimethoxy-phenanthren-1-yl)-5-methoxy-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trifluoro-methanesulfonic acid 2-(7,8-dimethoxy-phenanthren-1-yl)-5-methoxy-phenyl ester

There total 4 articles about Trifluoro-methanesulfonic acid 2-(7,8-dimethoxy-phenanthren-1-yl)-5-methoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2-(7,8-Dimethoxy-phenanthren-1-yl)-5-methoxy-phenol (149456-49-5) → Trifluoro-methanesulfonic acid 2-(7,8-dimethoxy-phenanthren-1-yl)-5-methoxy-phenyl ester (172980-29-9)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jo00129a064

Reference yield:

3-methoxy-2-(trimethylsilyl)-1-(methoxymethoxy)benzene (89321-21-1) → Trifluoro-methanesulfonic acid 2-(7,8-dimethoxy-phenanthren-1-yl)-5-methoxy-phenyl ester (172980-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi, MgBr₂, 2.) Ni(dppe)Cl₂ / 1.) ether, hexane, 4 h, r.t., 2.) ether, -78 deg C to r.t.; reflux, 12 h

2: 77 percent / 2 N aq. HCl / tetrahydrofuran / 24 h / 65 °C

3: 86 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

With 2,6-dimethylpyridine; hydrogenchloride; n-butyllithium; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; magnesium bromide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00129a064

Reference yield:

8-Bromo-1,2-dimethoxyphenanthrene → Trifluoro-methanesulfonic acid 2-(7,8-dimethoxy-phenanthren-1-yl)-5-methoxy-phenyl ester (172980-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi, MgBr₂, 2.) Ni(dppe)Cl₂ / 1.) ether, hexane, 4 h, r.t., 2.) ether, -78 deg C to r.t.; reflux, 12 h

2: 77 percent / 2 N aq. HCl / tetrahydrofuran / 24 h / 65 °C

3: 86 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

With 2,6-dimethylpyridine; hydrogenchloride; n-butyllithium; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; magnesium bromide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00129a064

upstream raw materials:

trifluoromethylsulfonic anhydride

2-(7,8-Dimethoxy-phenanthren-1-yl)-5-methoxy-phenol

3-methoxy-2-(trimethylsilyl)-1-(methoxymethoxy)benzene

[3-(7,8-Dimethoxy-phenanthren-1-yl)-6-methoxy-2-methoxymethoxy-phenyl]-trimethyl-silane