Technology Process of [2-Methoxy-6-(methoxymethoxy)phenyl](trimethyl)silane
There total 2 articles about [2-Methoxy-6-(methoxymethoxy)phenyl](trimethyl)silane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tert.-butyl lithium;
Yield given. Multistep reaction;
1.) hexane, pentane, THF, 2h, 0 degC 2.) room temp., 20h;
DOI:10.1021/jo00183a036
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diisopropylethylamine / CH2Cl2 / 0 °C
2: 1) t-BuLi / 1) hexane, 0 deg C, 3 h
With
tert.-butyl lithium; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) tert-butyllithium / 1.) hexane, pentane, 0 deg C, 4.5h 2.) THF, 2h, 0-10 deg C
2: 92 percent / pyridine / 0.5 h / 100 - 110 °C
3: 87 percent / tetraethylammonium fluoride / tetrahydrofuran / 24 h / Ambient temperature
4: 83 percent / H2 / 10percent Pd/C / ethanol; ethyl acetate / 12 h / 760 Torr / Ambient temperature
5: 76 percent / tetrahydrofuran; propan-2-ol / 20 h / Ambient temperature
With
pyridine; hydrogen; tert.-butyl lithium; tetraethylammonium fluoride;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; ethyl acetate; isopropyl alcohol;
DOI:10.1021/jo00183a036
