4-(3-[6-(3-(4-[5-(6'-(3-[3-(3-hex-5-ynyloxyphenyl)-prop-2-ynyloxy]-prop-1-ynyl)-[2,2']bipyridinyl-6-yl)-pent-4-ynyloxy]-phenyl)-propyl)-pyridin-2-yl]propyl)phenol

Base Information

• Chemical Name: 4-(3-[6-(3-(4-[5-(6'-(3-[3-(3-hex-5-ynyloxyphenyl)-prop-2-ynyloxy]-prop-1-ynyl)-[2,2']bipyridinyl-6-yl)-pent-4-ynyloxy]-phenyl)-propyl)-pyridin-2-yl]propyl)phenol
• CAS No.: 1357263-64-9
• Molecular Formula: C₅₆H₅₃N₃O₄
• Molecular Weight: 832.055
• Mol file: 1357263-64-9.mol

Synonyms:4-(3-[6-(3-(4-[5-(6'-(3-[3-(3-hex-5-ynyloxyphenyl)-prop-2-ynyloxy]-prop-1-ynyl)-[2,2']bipyridinyl-6-yl)-pent-4-ynyloxy]-phenyl)-propyl)-pyridin-2-yl]propyl)phenol

Chemical Property of 4-(3-[6-(3-(4-[5-(6'-(3-[3-(3-hex-5-ynyloxyphenyl)-prop-2-ynyloxy]-prop-1-ynyl)-[2,2']bipyridinyl-6-yl)-pent-4-ynyloxy]-phenyl)-propyl)-pyridin-2-yl]propyl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-[6-(3-(4-[5-(6'-(3-[3-(3-hex-5-ynyloxyphenyl)-prop-2-ynyloxy]-prop-1-ynyl)-[2,2']bipyridinyl-6-yl)-pent-4-ynyloxy]-phenyl)-propyl)-pyridin-2-yl]propyl)phenol

There total 10 articles about 4-(3-[6-(3-(4-[5-(6'-(3-[3-(3-hex-5-ynyloxyphenyl)-prop-2-ynyloxy]-prop-1-ynyl)-[2,2']bipyridinyl-6-yl)-pent-4-ynyloxy]-phenyl)-propyl)-pyridin-2-yl]propyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2,6-bis(3-(4-hydroxyphenyl)-propyl)-pyridine + toluene-4-sulfonic acid 5-(6'-(3-[3-(3-hex-5-ynyloxy-phenyl)-prop-2-ynyloxy]prop-1-ynyl)-[2,2']bipyridinyl-6-yl)-pent-4-ynyl ester (1357263-61-6) → 4-(3-[6-(3-(4-[5-(6'-(3-[3-(3-hex-5-ynyloxyphenyl)-prop-2-ynyloxy]-prop-1-ynyl)-[2,2']bipyridinyl-6-yl)-pent-4-ynyloxy]-phenyl)-propyl)-pyridin-2-yl]propyl)phenol (1357263-64-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

DOI:10.1002/anie.201105012

Reference yield:

dipropargyl ether (6921-27-3) → 4-(3-[6-(3-(4-[5-(6'-(3-[3-(3-hex-5-ynyloxyphenyl)-prop-2-ynyloxy]-prop-1-ynyl)-[2,2']bipyridinyl-6-yl)-pent-4-ynyloxy]-phenyl)-propyl)-pyridin-2-yl]propyl)phenol (1357263-64-9)

Guidance literature:

Multi-step reaction with 5 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 0.33 h / 65 °C / 760.05 Torr / Inert atmosphere; Microwave irradiation

2: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / methanol / 0.33 h / 65 °C / 760.05 Torr / Inert atmosphere; Microwave irradiation

3: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

4: triethylamine / dichloromethane / 18 h / 0 - 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Sonogashira coupling / 2: Sonogashira coupling;

DOI:10.1002/anie.201105012

Reference yield:

6,6'-Dibromo-2,2'-bipyridine (49669-22-9) → 4-(3-[6-(3-(4-[5-(6'-(3-[3-(3-hex-5-ynyloxyphenyl)-prop-2-ynyloxy]-prop-1-ynyl)-[2,2']bipyridinyl-6-yl)-pent-4-ynyloxy]-phenyl)-propyl)-pyridin-2-yl]propyl)phenol (1357263-64-9)

Guidance literature:

Multi-step reaction with 5 steps

1: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / methanol; toluene / 18 h / Inert atmosphere; Reflux

2: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / methanol / 0.33 h / 65 °C / 760.05 Torr / Inert atmosphere; Microwave irradiation

3: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

4: triethylamine / dichloromethane / 18 h / 0 - 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; caesium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Sonogashira coupling / 2: Sonogashira coupling;

DOI:10.1002/anie.201105012

upstream raw materials:

toluene-4-sulfonic acid 5-(6'-(3-[3-(3-hex-5-ynyloxy-phenyl)-prop-2-ynyloxy]prop-1-ynyl)-[2,2']bipyridinyl-6-yl)-pent-4-ynyl ester

3-(3-(3-[6'-(5-hydroxy-pent-1-ynyl)-[2,2']bipyridinyl-6-yl]-prop-2-ynyloxy)prop-1-ynyl)phenol

5-(6'-(3-[3-(3-hex-5-ynyloxy-phenyl)-prop-2-ynyloxy]-prop-1-ynyl)-[2,2']bipyridinyl-6-yl)pent-4-yn-1-ol

5-(6'-bromo-[2,2']bipyridinyl-6-yl)-pent-4-yn-1-ol

Downstream raw materials:

C₈₉H₈₄N₈O₆