3-(3-(3-[6'-(5-hydroxy-pent-1-ynyl)-[2,2']bipyridinyl-6-yl]-prop-2-ynyloxy)prop-1-ynyl)phenol

Base Information

Chemical Name:3-(3-(3-[6'-(5-hydroxy-pent-1-ynyl)-[2,2']bipyridinyl-6-yl]-prop-2-ynyloxy)prop-1-ynyl)phenol
CAS No.:1357263-59-2
Molecular Formula:C₂₇H₂₂N₂O₃
Molecular Weight:422.483
Hs Code.:

Synonyms:3-(3-(3-[6'-(5-hydroxy-pent-1-ynyl)-[2,2']bipyridinyl-6-yl]-prop-2-ynyloxy)prop-1-ynyl)phenol

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Chemical Property of 3-(3-(3-[6'-(5-hydroxy-pent-1-ynyl)-[2,2']bipyridinyl-6-yl]-prop-2-ynyloxy)prop-1-ynyl)phenol

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Technology Process of 3-(3-(3-[6'-(5-hydroxy-pent-1-ynyl)-[2,2']bipyridinyl-6-yl]-prop-2-ynyloxy)prop-1-ynyl)phenol

There total 4 articles about 3-(3-(3-[6'-(5-hydroxy-pent-1-ynyl)-[2,2']bipyridinyl-6-yl]-prop-2-ynyloxy)prop-1-ynyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1357263-58-1
3-(3-prop-2-ynyloxy-prop-1-ynyl)phenol

: 1357263-56-9
5-(6'-bromo-[2,2']bipyridinyl-6-yl)-pent-4-yn-1-ol

: 1357263-59-2
3-(3-(3-[6'-(5-hydroxy-pent-1-ynyl)-[2,2']bipyridinyl-6-yl]-prop-2-ynyloxy)prop-1-ynyl)phenol

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine; In methanol; at 65 ℃; for 0.333333h; under 760.051 Torr; Inert atmosphere; Microwave irradiation;
DOI:10.1002/anie.201105012

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 1357263-59-2
3-(3-(3-[6'-(5-hydroxy-pent-1-ynyl)-[2,2']bipyridinyl-6-yl]-prop-2-ynyloxy)prop-1-ynyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / methanol; toluene / 18 h / Inert atmosphere; Reflux

2: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / methanol / 0.33 h / 65 °C / 760.05 Torr / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine; In methanol; toluene; 1: Sonogashira coupling / 2: Sonogashira coupling;
DOI:10.1002/anie.201105012

Reference yield:

: 6921-27-3
dipropargyl ether

: 1357263-59-2
3-(3-(3-[6'-(5-hydroxy-pent-1-ynyl)-[2,2']bipyridinyl-6-yl]-prop-2-ynyloxy)prop-1-ynyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 0.33 h / 65 °C / 760.05 Torr / Inert atmosphere; Microwave irradiation

2: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / methanol / 0.33 h / 65 °C / 760.05 Torr / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; methanol; 1: Sonogashira coupling / 2: Sonogashira coupling;
DOI:10.1002/anie.201105012