N-methyl-N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide

Base Information

• Chemical Name: N-methyl-N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide
• CAS No.: 66366-25-4
• Molecular Formula: C₁₆H₁₄N₂O₄S
• Molecular Weight: 330.364

Synonyms:N-methyl-N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide

Chemical Property of N-methyl-N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of N-methyl-N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide

There total 2 articles about N-methyl-N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

saccharin sodium salt (128-44-9) + N-methyl-2-chloroacetanilide (2620-05-5) → N-methyl-N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-acetamide (66366-25-4)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 6h;

DOI:10.1002/jhet.5570200133

Reference yield:

→ N-methyl-N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-acetamide (66366-25-4)

Guidance literature:

Saccharin, Chloracetylmethylanilin;

Reference yield: 73.0%

N-methyl-N-phenyl-2-(1,1,3-trioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-acetamide (66366-25-4) → 4-Hydroxy-N-methyl-N-phenyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (66366-26-5)

Guidance literature:

With sodium isopropylate; In isopropyl alcohol; at 140 ℃; for 0.166667h;

DOI:10.1002/jhet.5570200133

upstream raw materials:

saccharin sodium salt

N-methyl-2-chloroacetanilide

Downstream raw materials:

2-{[(Methyl-phenyl-carbamoyl)-methyl]-sulfamoyl}-benzoic acid methyl ester

4-Hydroxy-N-methyl-N-phenyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

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