(3S,4S)-3-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester

Base Information

Chemical Name:(3S,4S)-3-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester
CAS No.:130405-85-5
Molecular Formula:C₂₆H₄₀N₂O₆
Molecular Weight:476.613
Hs Code.:

Synonyms:(3S,4S)-3-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester

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Chemical Property of (3S,4S)-3-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester

Chemical Property:

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Technology Process of (3S,4S)-3-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester

There total 3 articles about (3S,4S)-3-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146136-24-5,146136-25-6
(S)-3-Amino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester

: 501-53-1,94274-21-2
benzyl chloroformate

: 130405-85-5
(3S,4S)-3-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester

: 130405-86-6
(3R,4S)-3-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 1h; Yield given. Yields of byproduct given;
DOI:10.1021/jm00105a022

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 130405-85-5
(3S,4S)-3-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / tetrahydrofuran / Ambient temperature

2: NH₃ (gas) / ethanol / 16 h / 100 °C

3: Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 0 °C

With dmap; ammonia; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00105a022

Reference yield:

: 114371-49-2
ethyl -5-cyclohexyl-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-pentenoate

: 130405-85-5
(3S,4S)-3-Benzyloxycarbonylamino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃ (gas) / ethanol / 16 h / 100 °C

2: Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 0 °C

With dmap; ammonia; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00105a022