114371-49-2

Upstream product

• 98105-42-1 (S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 103322-56-1 tert-butyl [(1S)-2-cyclohexyl-1-(hydroxymethyl)ethyl]carbamate 

Downstream Products

• 146136-24-5 (S)-3-Amino-4-tert-butoxycarbonylamino-5-cyclohexyl-pentanoic acid ethyl ester 
• 114371-50-5 1,1-dimethylethyl -<1-(cyclohexylmethyl)-4-hydroxy-2-butenyl>carbamate 
• 298208-82-9 (E)-(S)-4-Amino-5-cyclohexyl-pent-2-en-1-ol 
• 257296-67-6 (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyl-5-vinyloxazoline 
• 257296-61-0 (-)-N-((2S,3S)-3-hydroxy-1-cyclohexyl-4-pentenyl)benzamide 
• 257296-73-4 (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline 
• 298208-78-3 (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyloxazoline-5-acetic acid 
• 257296-55-2 N-((2S)-5-acetoxy-1-cyclohexyl-3-butenyl)benzamide 
• 1057661-66-1 (S)-3,4-Diamino-5-cyclohexyl-pentanoic acid ethyl ester 
• 146136-19-8 1,1-dimethylethyl -<1-(cyclohexylmethyl)-4-(2,2,2-trichloro-1-iminoethoxy)-2-butenyl>carbamate 
• 130405-96-8 (3R,4S)-3-Amino-5-cyclohexyl-4-[(S)-2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoic acid {(S)-3-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide 
• 130405-96-8 N₄-<(2S)-2-(8-Isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)-3-pyridin-3-ylpropanoyl>-(S)-CDAPA-Leu pyridin-2-ylmethylamide 
• 130405-96-8 (3R,4S)-3-Amino-5-cyclohexyl-4-[(R)-2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoic acid {(S)-3-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide 
• 130405-96-8 N₄-<(2R)-2-(8-isobutyl-6-phenyl-1,2,4-triazolo<4,3-a>pyrazin-3-yl)-3-pyridin-3-ylpropanoyl>-(S)-CDAPA-Leu pyridin-2-ylmethylamide 

Relevant academic research and scientific papers

Stereoselective intramolecular cyclization of allyl and homoallyl benzamide via π-allylpalladium complex catalyzed by Pd(0)

The transformation of acyclic allylic benzamides 4 and homoallylic benzamides 12 to vinyl oxazolines 3 is achieved in the presence of base by the catalysis and Pd(0) in high yield and with high diastereoselectivity. Especially, in the case of homoallylic benzamides 12, trans-oxazolines 3 are formed exclusively or predominantly over cis-oxazolines 8, irrespective of the composition of their stereoisomers. The reaction is believed to proceed via the same π-allylpalladium complex that arises from either primary or secondary allylic acetates. We applied this method to the syntheses of β- amino-α-hydroxy acids 1 and γ-amino-β-hydroxy acids 2, conveniently protected as oxazoline.

1,2,4-Triazolopyrazine Derivatives with Human Renin Inhibitory Activity. 3. Synthesis and Biological Properties of Aminodeoxystatine and Difluorostatone Derivatives

Two series of 1,2,4-triazolopyrazine derivatives with human renin inhibitory activity have been synthesized which incorporate the transition-state mimetics (3S,4S)- and (3R,4S)-5-cyclohexyl-3,4-diaminopentanoic acid ((S)- and (R)-CDAPA), and (4S)-4