Technology Process of (2S,5S)-N-<(benzyloxy)carbonyl>-2-<4-(benzoyloxy)butyl>-5-butylpyrrolidine
There total 10 articles about (2S,5S)-N-<(benzyloxy)carbonyl>-2-<4-(benzoyloxy)butyl>-5-butylpyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 46 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 1.5 h / Ambient temperature
2: 92 percent / CBr4, triphenylphosphine / CH2Cl2 / 0.17 h / 0 °C
3: 84 percent / triethylamine, H2 / 10percent Pd-C / methanol / 1 h / 760 Torr
4: 91 percent / 1 M tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature
5: thionyl chloride, triethylamine / CH2Cl2 / Ambient temperature
6: RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / 2 h / 0 °C
8: 20percent aq. K2CO3 / CH2Cl2 / ice bath
With
dmap; ruthenium trichloride; sodium periodate; thionyl chloride; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00045a034
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 46 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 1.5 h / Ambient temperature
2: 92 percent / CBr4, triphenylphosphine / CH2Cl2 / 0.17 h / 0 °C
3: 84 percent / triethylamine, H2 / 10percent Pd-C / methanol / 1 h / 760 Torr
4: 91 percent / 1 M tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature
5: thionyl chloride, triethylamine / CH2Cl2 / Ambient temperature
6: RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / 2 h / 0 °C
8: 20percent aq. K2CO3 / CH2Cl2 / ice bath
With
dmap; ruthenium trichloride; sodium periodate; thionyl chloride; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00045a034
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 84 percent / triethylamine, H2 / 10percent Pd-C / methanol / 1 h / 760 Torr
2: 91 percent / 1 M tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature
3: thionyl chloride, triethylamine / CH2Cl2 / Ambient temperature
4: RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / 2 h / 0 °C
6: 20percent aq. K2CO3 / CH2Cl2 / ice bath
With
ruthenium trichloride; sodium periodate; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00045a034
