Technology Process of 1-chloro-5-(2,5-dimethoxyphenyl)-2-pentanone
There total 5 articles about 1-chloro-5-(2,5-dimethoxyphenyl)-2-pentanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 57 percent / CHCl3 / 4 h / Heating
2: 47 percent / H2 / 10percent Pd/C / ethanol / 2 h
3: 1.) LDA / 1.) THF, -78 deg C, 40 min, 2.) THF, from -78 deg C to RT
4: 1.) N-chlorosuccinimide, 2.) citric acid / 1.) CH2Cl2, reflux, 1 h, 2.) MeOH, RT, 1,5 h
With
N-chloro-succinimide; hydrogen; citric acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
ethanol; chloroform;
DOI:10.1021/jm00073a009
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 47 percent / H2 / 10percent Pd/C / ethanol / 2 h
2: 1.) LDA / 1.) THF, -78 deg C, 40 min, 2.) THF, from -78 deg C to RT
3: 1.) N-chlorosuccinimide, 2.) citric acid / 1.) CH2Cl2, reflux, 1 h, 2.) MeOH, RT, 1,5 h
With
N-chloro-succinimide; hydrogen; citric acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
ethanol;
DOI:10.1021/jm00073a009
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 40percent aq. HClO4 / diethyl ether / 0.75 h
2: 57 percent / CHCl3 / 4 h / Heating
3: 47 percent / H2 / 10percent Pd/C / ethanol / 2 h
4: 1.) LDA / 1.) THF, -78 deg C, 40 min, 2.) THF, from -78 deg C to RT
5: 1.) N-chlorosuccinimide, 2.) citric acid / 1.) CH2Cl2, reflux, 1 h, 2.) MeOH, RT, 1,5 h
With
N-chloro-succinimide; perchloric acid; hydrogen; citric acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
diethyl ether; ethanol; chloroform;
DOI:10.1021/jm00073a009
