33567-62-3

Usage

Uses

Used in Pharmaceutical Synthesis:
(2,5-dimethoxyphenyl)acetaldehyde is utilized as a key intermediate in the production of various pharmaceuticals. Its reactivity allows it to be incorporated into the molecular structures of drugs, contributing to their therapeutic properties.
Used in Organic Compound Synthesis:
(2,5-dimethoxyphenyl)acetaldehyde serves as a versatile building block in the synthesis of a range of organic compounds, leveraging its ability to participate in multiple types of chemical reactions to form complex molecules.
Used in Dye Production:
(2,5-dimethoxyphenyl)acetaldehyde is employed as a precursor in the manufacturing process of dyes. Its chemical structure contributes to the color properties of the dyes, making it a valuable component in this industry.
Used in Fragrance Industry:
In the fragrance industry, (2,5-dimethoxyphenyl)acetaldehyde is used to create scented compounds. Its chemical makeup allows it to contribute to the development of distinctive and complex fragrances.
Used in Industrial Chemical Production:
(2,5-dimethoxyphenyl)acetaldehyde is also a component in the production of other industrial chemicals, where its reactivity and structural features are harnessed to produce a variety of chemical products.
Used in Biological Research:
(2,5-dimethoxyphenyl)acetaldehyde has been the subject of biological studies, particularly for its potential role as a precursor in the synthesis of psychoactive substances. This research is important for understanding its effects and potential applications in medicine and pharmacology.

Upstream product

• 6202-39-7 homogentisic acid methyl ester dimethyl ether 
• 1758-25-4 (2,5-dimethoxyphenyl)acetic acid 
• 66469-86-1 ethyl (2,5-dimethoxyphenyl)acetate 
• 1201-38-3 2',5'-dimethoxyacetophenone 
• 150-76-5 4-methoxy-phenol 
• 584-82-7 2-allyl-4-methoxyphenol 
• 13391-35-0 allyl (4-methoxyphenyl) ether 
• 19754-22-4 2-allyl-1,4-dimethoxybenzene 
• 7417-19-8 2-(2,5-dimethoxyphenyl)ethanol 
• 33567-56-5 3-(2,5-Dimethoxy-phenyl)-oxirane-2-carboxylic acid methyl ester 

Downstream Products

• 113590-20-8 (E and Z)-N-<2-(2,5-dimethoxyphenyl)ethenyl>formamide 
• 66397-39-5 2-Methyl-3-hydroxy-4-(2',5'-dimethoxyphenyl)-but-1-en 
• 109979-72-8 6-(2,5-dimethoxyphenyl)-1,4-dimethoxynaphthalene 
• 1399639-06-5 C₂₀H₂₀N₂O₇S 
• 1612882-33-3 C₁₁H₁₆O₃ 
• 1612882-42-4 C₁₁H₁₅IO₂ 
• 1612882-16-2 C₁₇H₁₆O₃S₂ 
• 1259330-61-4 sparstolonin B 
• 1356862-37-7 C₂₆H₃₅FN₂O₃ 
• 1088496-58-5 1,1-dibromo-3-(2,5-dimethoxyphenyl)propene 
• 66397-42-0 Ethyl-2.6-dimethyl-8-(2'.5'-dimethoxyphenyl)octa-2E_.6E-dienoat 

Relevant academic research and scientific papers

Total synthesis of sparstolonin B via a palladium-catalyzed aldehyde α-arylation

A concise and convergent total synthesis of sparstolonin B was developed. A palladium-catalyzed aldehyde α-arylation was utilized to construct the carbon skeleton of the natural product. A subsequent simple one-pot procedure effected global deprotection and closure of the final two rings via an unusual autoredox mechanism for the conversion of a bis-hydroquinone intermediate to the natural product. The 6 step synthetic sequence was realized in 18% overall yield.

A straightforward organocatalytic alkylation of 2-arylacetaldehydes: An approach towards bisabolanes

A highly stereoselective organocatalytic aalkylation of 2-arylacetaldehydes with a commercially available carbenium tetrafluoroborate is described. The stereoselective alkylation was carried out in acetonitrile/ water, under air in the presence of a commercially available imidazolidinone (MacMillan's catalyst). Key intermediates for the synthesis of bisabolanes were obtained through a simple chemistry. In particular a direct, enantioselective and facile synthesis of (R)-(-)-curcumene is described.

Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase

Bacillus anthracis, the causative agent of anthrax, poses a significant biodefense danger. Serious limitations in approved therapeutics and the generation of resistance have produced a compelling need for new therapeutic agents against this organism. Baci

2,4-Diaminothienopyrimidine Analogues of Trimetrexate and Piritrexim as Potential Inhibitors of Pneumocystis Carinii and Toxoplasma gondii Dihydrofolate Reductase

A series of eight previously undescribed 2,4-diaminothienopyrimidine analogues of the potent dihydrofolate reductase (DHFR) inhibitors trimetrexate (TMQ) and piritrexim (PTX) were synthesized as potential drugs against Pneumocystis carinii and Toxoplasma gondii, which are major causes of severe opportunistic infections in AIDS patients. 2,4-Diamino-5-methyl-6-(aryl/aralkyl)thienopyrimidines with 3,4,5-trimethoxy or 2,5-dimethoxy substitution in the aryl/aralkyl moiety and 2,4-diamino-5-(aryl/aralkyl)thienopyrimidines with 2,5-dimethoxy substitution in the aryl/aralkyl moiety were obtained by reaction of the corresponding 2-amino-3-cyanothiophenes with chloroformamidine hydrochloride.The aryl group in the 5,6-disubstituted analogues was either attached directly to the hetero ring or was separated from it by one or two carbons, whereas the aryl group in the 5-monosubstituted analogues was separated from the hetero ring by two or three carbons. 2-Amino-3-cyano-5-methyl-6-(aryl/alkyl)thiophene intermediates for the preparation of the 5,6-disubstituted analogues were prepared from ω-aryl-2-alkylidenemalononitriles and sulfur in the presence of a secondary amine, and 2-amino-3-cyano-4-(aryl/aralkyl)thiophene intermediates for the preparation of the 5-monosubstituted analogues were obtained from ω-aryl-1-chloro-2-alkylidenemalononitriles and sodium hydrosulfide.Synthetic routes to the heterofore unknown ylidenemalononitriles, and the ketone precursors thereof, were developed.The final products were tested in vitro as inhibitors of DHFR from Pneumocystis carinii, Toxoplasma gondii, rat liver, beef liver, and Lactobacillus casei.A select number of previously known 2,4-diaminothienopyrimidines lacking the 3,4,5-trimethoxyphenyl and 2,5-dimethoxyphenyl substitution pattern of TMQ and PTX, respectively, were also tested for comparison.None of the compounds was as potent as TMQ or PTX, and while some of them showed some selectivity in their binding to Pneumocystis carinii and Toxoplasma gondii versus rat liver DHFR, this effect was not deemed large enough to warrant further preclinical evaluation.

SYNTHESIS OF ERBSTATIN

A simple and convenient synthesis of the tyrosinespecific protein kinase inhibitor, erbstatin (1) from cheap and easily accessible 4-methoxyphenol is described.