5-[(biphenyl-4-yloxy)methyl]4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole

Base Information

• Chemical Name: 5-[(biphenyl-4-yloxy)methyl]4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole
• CAS No.: 1104067-91-5
• Molecular Formula: C₂₁H₁₆FN₃OS
• Molecular Weight: 377.442

Synonyms:5-[(biphenyl-4-yloxy)methyl]4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole

Chemical Property of 5-[(biphenyl-4-yloxy)methyl]4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole

Chemical Property:

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Technology Process of 5-[(biphenyl-4-yloxy)methyl]4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole

There total 3 articles about 5-[(biphenyl-4-yloxy)methyl]4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N1-[2-(biphenyl-4-yloxy)ethanoyl]-N4-(4-fluorophenyl)-thiosemicarbazide (905231-34-7) → 5-[(biphenyl-4-yloxy)methyl]4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole (1104067-91-5)

Guidance literature:

With triethylamine; In ethanol; Reflux;

DOI:10.1002/ardp.201100128

Reference yield:

4-Phenylphenol (92-69-3) → 5-[(biphenyl-4-yloxy)methyl]4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole (1104067-91-5)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetone / Reflux

2: hydrazine hydrate / 4 h / Reflux

3: ethanol / Reflux

4: triethylamine / ethanol / Reflux

With potassium carbonate; hydrazine hydrate; triethylamine; In ethanol; acetone;

DOI:10.1002/ardp.201100128

Reference yield:

2-(biphenyl-4-yloxy)acetic acid hydrazide (84161-08-0) → 5-[(biphenyl-4-yloxy)methyl]4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole (1104067-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Reflux

2: triethylamine / ethanol / Reflux

With triethylamine; In ethanol;

DOI:10.1002/ardp.201100128

upstream raw materials:

N₁-[2-(biphenyl-4-yloxy)ethanoyl]-N₄-(4-fluorophenyl)-thiosemicarbazide

4-Phenylphenol

2-(biphenyl-4-yloxy)acetic acid hydrazide

Downstream raw materials:

3-(2-phenethylthio)-5-[(4-biphenyloxy)methyl]-4-(4-fluorophenyl)-4H-1,2,4-triazole

2-{5-[(4-phenylphenoxy)methyl]-4-(4-fluorophenyl)-4H-1,2,4-triazol-3-ylthio}-1-(phenyl)ethanone

2-{5-[(4-biphenyloxy)methyl]-4-(4-fluorophenyl)-4H-1,2,4-triazol-3-ylthio}-1-(4-bromophenyl)ethanone

3-(4-nitrophenylmethylthio)-5-[(4-biphenyloxy)methyl]-4-(4-fluorophenyl)-4H-1,2,4-triazole

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