Technology Process of 3-O-benzoyl-2,6-dideoxy-2,2-difluoro-D-myo-inositol 1,4,5-tris(dibutyl phosphate)
There total 9 articles about 3-O-benzoyl-2,6-dideoxy-2,2-difluoro-D-myo-inositol 1,4,5-tris(dibutyl phosphate) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 93 percent / sodium hydride / dimethylformamide / 12 h
2: 98 percent / aq. HCl / methanol / 15 h / 60 °C
3: 80 percent / pyridine / 0.33 h / 10 °C
4: 80 percent / N-oxy-4-methylmorpholine; molecular sieves / tetra-n-propylammonium perruthenate / CH2Cl2 / 12 h
5: 62 percent / (diethylamino)sulfur trifluoride / CH2Cl2 / 20 h / 20 °C
6: 93 percent / hydrogen / Pd/C / ethyl acetate / 2 h / 155.14 Torr
7: 1H-tetrazole / acetonitrile / 3 h / 20 °C
8: t-BuOOH / acetonitrile; CH2Cl2 / 12 h / 20 °C
With
pyridine; 1H-tetrazole; hydrogenchloride; tert.-butylhydroperoxide; molecular sieve; diethylamino-sulfur trifluoride; hydrogen; sodium hydride; 4-methylmorpholine N-oxide;
palladium on activated charcoal; tetrapropylammonium perruthennate;
In
methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(00)01112-1
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 80 percent / pyridine / 0.33 h / 10 °C
2: 80 percent / N-oxy-4-methylmorpholine; molecular sieves / tetra-n-propylammonium perruthenate / CH2Cl2 / 12 h
3: 62 percent / (diethylamino)sulfur trifluoride / CH2Cl2 / 20 h / 20 °C
4: 93 percent / hydrogen / Pd/C / ethyl acetate / 2 h / 155.14 Torr
5: 1H-tetrazole / acetonitrile / 3 h / 20 °C
6: t-BuOOH / acetonitrile; CH2Cl2 / 12 h / 20 °C
With
pyridine; 1H-tetrazole; tert.-butylhydroperoxide; molecular sieve; diethylamino-sulfur trifluoride; hydrogen; 4-methylmorpholine N-oxide;
palladium on activated charcoal; tetrapropylammonium perruthennate;
In
dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4020(00)01112-1
