Methyl 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

Base Information

Chemical Name:Methyl 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate
CAS No.:263570-28-1
Molecular Formula:C14H19 N O4
Molecular Weight:265.3
Hs Code.:2933499090
DSSTox Substance ID:DTXSID90392289
Nikkaji Number:J1.246.845H
ChEMBL ID:CHEMBL1723360
Mol file:263570-28-1.mol

Synonyms:263570-28-1;Methyl 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate;Methyl2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate;Methyl (6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate;Methyl (6,7-dimethoxy-1,2,3,4-tetrahydro-1-isoquinolinyl)acetate;MLS000770701;CHEMBL1723360;DTXSID90392289;HMS2666B03;STL191169;AKOS000122350;AKOS016040129;CS-13266;SMR000343900;A5239;FT-0717375;FT-0774423;EN300-40641;A51032;Z55928843;1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinoline-1-acetic acid methyl ester

Suppliers and Price of Methyl 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate 95+%
5g
$ 1067.00

Crysdot
Methyl2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate 95+%
1g
$ 353.00

Chemenu
methyl2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate 95%
1g
$ 333.00

Chemenu
methyl2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate 95%
5g
$ 1006.00

American Custom Chemicals Corporation
1-ISOQUINOLINEACETIC ACID, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-, METHYL ESTER 95.00%
5MG
$ 498.41

Alichem
Methyl2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate
5g
$ 855.36

Alichem
Methyl2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate
1g
$ 288.00

Total 18 raw suppliers

Chemical Property of Methyl 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

Chemical Property:

PSA：56.79000
LogP:1.78250
Storage Temp.:2-8°C
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:265.13140809
Heavy Atom Count:19
Complexity:310

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(NCCC2=C1)CC(=O)OC)OC

Technology Process of Methyl 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

There total 2 articles about Methyl 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: methyl 3-{[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]amino}prop-2-enoate

: 263570-28-1,417725-91-8
methyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-acetate

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 3h; Heating;
DOI:10.1021/jo0107857

Reference yield: 49.0%

: methyl 3-{[2-(2-bromo-4,5-dimethoxyphenyl)ethyl]amino}prop-2-enoate

: 263570-28-1,417725-91-8
methyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-acetate

: methyl 3-{[2-(3,4-dimethoxyphenyl)ethyl]amino}prop-2-enoate

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 3h; Heating;
DOI:10.1021/jo0107857

Reference yield:

: 263570-28-1,417725-91-8
methyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-acetate

: 18647-21-7
7,8-Dimethoxy-10-benzoyl-4,5-dihydro-1H-1,4-epimino-benzocyclohepten-3(2H)-on

Guidance literature:: Multi-step reaction with 10 steps

1.1: Et₃N; DMAP / ethyl acetate / 24 h / 20 °C

2.1: LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

3.1: pyridine-SO₃/DMSO; Et₃N / CH₂Cl₂ / 2 h / 0 °C

4.1: 62 percent / PPh₃; t-BuOK / toluene / 1 h / -20 °C

5.1: n-BuLi; TMEDA / tetrahydrofuran / 1 h / -78 °C

5.2: 75 percent / tetrahydrofuran / 24 h / 20 °C

6.1: TMS-I / acetonitrile / 0.25 h / 20 °C

7.1: Et₃N; DMAP / benzene / 24 h / 20 °C

8.1: 95 percent / Bu₃SnH; AIBN / toluene / 2 h / Heating

9.1: 78 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

10.1: 4 percent aq. OsO₄ / tetrahydrofuran / 0.25 h / 0 °C

10.2: 27 percent / NaIO₄ / tetrahydrofuran; H₂O / 24 h / 20 °C

With dmap; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; 2,2'-azobis(isobutyronitrile); trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; potassium tert-butylate; tri-n-butyl-tin hydride; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; acetonitrile; benzene; 1.1: Acylation / 2.1: Reduction / 3.1: Oxidation / 4.1: Condensation / 5.1: Elimination / 5.2: Substitution / 6.1: Substitution / 7.1: Acylation / 8.1: Reduction / 9.1: Substitution / 10.1: Oxidation / 10.2: Oxidation;
DOI:10.3987/COM-99-S91